Spastin 抗体
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- 抗原 See all Spastin (SPAST) 抗体
- Spastin (SPAST)
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Spastin antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 免疫原
- spastin
- 亚型
- IgG
- Top Product
- Discover our top product SPAST Primary Antibody
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anti-Spastin (SPAST) (AA 200-304) antibody
SPAST 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2F5 unconjugated
anti-Spastin (SPAST) (AA 551-616) antibodySPAST 适用: 小鼠, 大鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Spastin (SPAST) antibodySPAST 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Spastin (SPAST) (AA 200-304) antibodySPAST 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3A12 unconjugated
anti-Spastin (SPAST) antibodySPAST 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Spastin (SPAST) antibodySPAST 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, Coat, StM 宿主: 小鼠 Monoclonal Sp 3G11-1 unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 缓冲液
- PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freeze / thaw cycles.
- 储存条件
- -20 °C
- 有效期
- 12 months
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- 抗原
- Spastin (SPAST)
- 别名
- SPAST (SPAST 产品)
- 别名
- CG5977 antibody, D-spastin antibody, Dmel\\CG5977 antibody, Dspastin antibody, Spas antibody, zgc:85952 antibody, SPAST antibody, spg4 antibody, LOC100224472 antibody, ADPSP antibody, FSP2 antibody, SPG4 antibody, Spg4 antibody, mKIAA1083 antibody, spastin antibody, spastin S homeolog antibody, spas antibody, spast antibody, SPAST antibody, Spast antibody, spast.S antibody
- 背景
- Synonyms:Kiaa1083, Spg4 Background:ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated(PubMed:19141076 PubMed:20530212). Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold(By similarity). Severing activity is not dependent on tubulin acetylation or detyrosination(By similarity). Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation(By similarity). It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia(By similarity). SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex(By similarity). Recruited at the midbody, probably by IST1, and participates to membrane fission during abscission together with the ESCRT-III complex(By similarity). Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase(By similarity). Required for membrane traffic from the endoplasmic reticulum(ER) to the Golgi and endosome recycling(By similarity). Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing(By similarity). Probably plays a role in axon growth and the formation of axonal branches(PubMed:18234839). Isoform 1: Involved in lipid metabolism by regulating the size and distribution of lipid droplets.
- 基因ID
- 50850
- UniProt
- Q9QYY8
- 途径
- Microtubule Dynamics, M Phase, Regulation of Cell Size
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