TET2 抗体 (Internal Region)
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Quick Overview for TET2 抗体 (Internal Region) (ABIN569654)
抗原
See all TET2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- Internal Region
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序列
- C-PHPQSNNDQQ REGSF
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特异性
- This antibody is expected to recognize both reported isoforms (NP_001120680.1 and NP_060098.3).
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Canine (Dog).
Species reactivity (tested):Human. -
纯化方法
- Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
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免疫原
- Peptide with sequence from the internal region of the protein sequence according to NP_001120680.1 and NP_060098.3. Genename: TET2
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anti-Tet Methylcytosine Dioxygenase 2 (TET2) (AA 1833-2002) antibody
TET2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tet Methylcytosine Dioxygenase 2 (TET2) antibodyTET2 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 5H8C7 unconjugated
anti-Tet Methylcytosine Dioxygenase 2 (TET2) antibodyTET2 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tet Methylcytosine Dioxygenase 2 (TET2) antibodyTET2 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 5H8B3 unconjugated
anti-Tet Methylcytosine Dioxygenase 2 (TET2) (AA 1833-2002) antibodyTET2 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Tet Methylcytosine Dioxygenase 2 (TET2) (Internal Region) antibodyVerified TET2 适用: 人 ELISA, IHC, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Tet Methylcytosine Dioxygenase 2 (TET2) (AA 100-150) antibodyTET2 适用: 人 WB, IP, IHC (fp) 宿主: 兔 Polyclonal unconjugated
anti-Tet Methylcytosine Dioxygenase 2 (TET2) (AA 528-554), (N-Term) antibodyTET2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB37907 unconjugated
anti-Tet Methylcytosine Dioxygenase 2 (TET2) (AA 1-300) antibodyTET2 适用: 人 WB, IP 宿主: 小鼠 Monoclonal 21F11 unconjugated
anti-Tet Methylcytosine Dioxygenase 2 (TET2) (AA 528-554) antibodyTET2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- Tris saline, pH ~7.3 with 0.02 % Sodium Azide and 0.5 % BSA
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))
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别名
- TET2
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背景
- TET2 is frequently mutated in myelodysplastic syndromes, a heterogeneous group of closely related clonal hematopoietic disorders. All are characterized by a hypercellular or hypocellular bone marrow with impaired morphology and maturation, dysplasia of the myeloid, megakaryocytic and/or erythroid lineages, and peripheral blood cytopenias resulting from ineffective blood cell production. Included diseases are: refractory anemia (RA), refractory anemia with ringed sideroblasts (RARS), refractory anemia with excess blasts (RAEB), refractory cytopenia with multilineage dysplasia and ringed sideroblasts (RCMD-RS). Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative disease. Myelodysplastic syndromes are considered a premalignant condition in a subgroup of patients that often progresses to acute myeloid leukemia (AML). Bone marrow samples from patients display uniformly low levels of hmC in genomic DNA compared to bone marrow samples from healthy controls as well as hypomethylation relative to controls at the majority of differentially methylated CpG sites. It Catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (hmC). Plays an important role in myelopoiesis. The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation. TET2 is Broadly expressed. Highly expressed in hematopoietic cells, highest expression observed in granulocytes. Expression is reduced in granulocytes from peripheral blood of patients affected by myelodysplastic syndromes.Synonyms: KIAA1546, Methylcytosine dioxygenase TET2
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基因ID
- 54790
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NCBI登录号
- NP_001120680
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UniProt
- Q6N021
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途径
- Warburg Effect
抗原
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