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TET2 抗体 (AA 1-300)

This 小鼠 单克隆 antibody specifically detects TET2 in WB, IP, IF 和 ICC. It exhibits reactivity toward 人. It has been mentioned in 2+ publications
产品编号 ABIN2668527
发货至: 中国
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Quick Overview for TET2 抗体 (AA 1-300) (ABIN2668527)

抗原

See all TET2 抗体
TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

适用

  • 56
  • 24
  • 16

宿主

  • 48
  • 9
  • 1
小鼠

克隆类型

  • 49
  • 9
单克隆

标记

  • 34
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This TET2 antibody is un-conjugated

应用范围

  • 35
  • 18
  • 11
  • 10
  • 8
  • 8
  • 7
  • 6
  • 5
  • 4
  • 1
  • 1
Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF), Immunocytochemistry (ICC)

克隆位点

21F11
  • 抗原表位

    • 13
    • 13
    • 8
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 1-300

    原理

    Tet2 antibody (mAb) (Clone 21F11)

    纯化方法

    Protein A Chromatography

    免疫原

    This antibody was raised against a recombinant protein corresponding to amino acids 1-300 of human Tet2.

    亚型

    IgG1 kappa
  • 应用备注

    IP: 1 - 2 µL per IP WB: 1 - 2 μg/mL dilution

    限制

    仅限研究用
  • 浓度

    1 μg/μL

    缓冲液

    Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions,Keep all reagents on ice when not in storage

    储存条件

    -20 °C

    储存方法

    Some products may be shipped at room temperature. This will not affect their stability or performance. Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.

    有效期

    24 months
  • Wallner, Schröder, Leitão, Berulava, Haak, Beißer, Rahmann, Richter, Manke, Bönisch, Arrigoni, Fröhler, Klironomos, Chen, Rajewsky, Müller, Ebert, Lengauer, Barann, Rosenstiel, Gasparoni, Nordström et al.: "Epigenetic dynamics of monocyte-to-macrophage differentiation. ..." in: Epigenetics & chromatin, Vol. 9, pp. 33, (2016) (PubMed).

    Gong, Guo, Niu, Jin, Zhang, Shi, Zhang, Li, Chen, Ma: "Epigenetic silencing of TET2 and TET3 induces an EMT-like process in melanoma." in: Oncotarget, Vol. 8, Issue 1, pp. 315-328, (2016) (PubMed).

  • 抗原

    TET2 (Tet Methylcytosine Dioxygenase 2 (TET2))

    别名

    Tet2

    背景

    Tet2 (tet methylcytosine dioxygenase 2) catalyzes the conversion of methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC). Plays an important role in myelopoiesis. The clear function of 5-hydroxymethylcytosine (hmC) is still unclear but it may influence chromatin structure and recruit specific factors or may constitute an intermediate component in cytosine demethylation and differentiation in the case of inflammation by regulating gene expression and macrophage differentiation.

    分子量

    220 kDa

    基因ID

    54790

    NCBI登录号

    NP_001120680

    途径

    Warburg Effect
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