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PSMB9 抗体 (Internal Region)

PSMB9 适用: 人, 小鼠, 大鼠, 犬, Pig, 兔, Cow WB, EIA 宿主: 山羊 Polyclonal unconjugated
产品编号 ABIN569589
发货至: 中国
  • 抗原 See all PSMB9 抗体
    PSMB9 (Proteasome (Prosome, Macropain) Subunit, beta Type, 9 (Large Multifunctional Peptidase 2) (PSMB9))
    抗原表位
    • 15
    • 13
    • 11
    • 8
    • 8
    • 2
    • 2
    • 1
    • 1
    • 1
    Internal Region
    适用
    • 46
    • 33
    • 15
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 犬, Pig, 兔, Cow
    宿主
    • 63
    • 6
    • 1
    山羊
    克隆类型
    • 61
    • 9
    多克隆
    标记
    • 30
    • 7
    • 6
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    This PSMB9 antibody is un-conjugated
    应用范围
    • 52
    • 31
    • 20
    • 13
    • 13
    • 11
    • 9
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Enzyme Immunoassay (EIA)
    序列
    C-RNISYKYRED
    特异性
    Recognizes PSMB9
    交叉反应 (详细)
    Species reactivity (expected):Mouse, Canine (Dog), Cow, Pig, Rabbit.
    Species reactivity (tested):Human, Rat.
    纯化方法
    Ammonium Sulphate Precipitation followed by antigen Affinity Chromatography using the immunizing peptide
    免疫原
    Peptide with sequence from the internal region of the protein sequence according to NP_002791.1.
    Top Product
    Discover our top product PSMB9 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    PSMB9 (Proteasome (Prosome, Macropain) Subunit, beta Type, 9 (Large Multifunctional Peptidase 2) (PSMB9))
    别名
    PSMB9 (PSMB9 产品)
    别名
    LMP2 antibody, ring12 antibody, MHC-linked antibody, psmb9b antibody, lmp2 antibody, lmp2b antibody, psmb9 antibody, Lmp-2 antibody, Lmp2 antibody, PSMB6i antibody, RING12 antibody, beta1i antibody, psmb9-A antibody, macropain antibody, prosome antibody, wu:fa66f04 antibody, wu:fj22d05 antibody, zgc:91842 antibody, psmb9a antibody, proteasome subunit beta 9 antibody, LMP2 antibody, proteasome subunit beta type-9b antibody, proteasome (prosome, macropain) subunit, beta type 9 (large multifunctional peptidase 2) antibody, proteasome subunit beta 9 S homeolog antibody, proteasome subunit beta 9a antibody, proteasome (prosome, macropain) subunit, beta type, 9a antibody, psmb9 antibody, PSMB9 antibody, psmb9-b antibody, Psmb9 antibody, psmb9.S antibody, psmb9a antibody
    背景
    Proteolytic degradation is critical to the maintenance of appropriate levels of short-lived and regulatory proteins as important and diverse as those involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signalling factors. The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus. Other proteins are degraded via the vacuolar pathway which includes endosomes, lysosomes, and the endoplasmic reticulum. The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. The PA28/11S REG Activator protein complex functions as a proteolytic activator. LMP2 is a catalytic subunit of the 20S proteasome and, upon interferon gamma-induction, replaces the delta subunit. LMP2 alters the specificity of the 20S proteasome and is critical for the production of MHC class I ligands, production of T-lymphocytes, and is suggested to increase the efficiency of antigen presentation of the immune response. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis (CF transmembrane regulator), Angelman's syndrome (E6-AP), and Liddle syndrome (endothelial sodium channels).Synonyms: LMP2, Macropain chain 7, Multicatalytic endopeptidase complex chain 7, PSMB6i, Proteasome 20S LMP2, Proteasome chain 7, Proteasome subunit beta type-9, Proteasome subunit beta-1i, RING12, Really interesting new gene 12 protein
    分子量
    23.3kDa (Human NP_002791.1)
    基因ID
    5698
    NCBI登录号
    NP_002791
    UniProt
    P28065
    途径
    Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA
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