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Bcl-2 抗体 (AA 118-165)

Name: Bcl-2 抗体 (AA 118-165)
SKU: ABIN5693065
Availability: OutOfStock

BCL2 适用: 人 WB, FACS, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

Western blot analysis of Bcl-2 using anti-Bcl-2 antibody . (Bcl-2 抗体 (AA 118-165))

IHC analysis of Bcl-2 using anti-Bcl-2 antibody . (Bcl-2 抗体 (AA 118-165))

IHC

2 images

(82 references)

产品编号 ABIN5693065

发货至: 中国

Datasheet as PDF

抗原 See all Bcl-2 (BCL2) 抗体

Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))
抗原表位
48

33

25

21

21

20

16

15

15

11

9

8

8

7

7

6

6

6

5

5

4

3

3

3

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 118-165
适用
375

153

151

32

24

20

14

7

5

4

4

1

1

1

1
人
宿主
300

108

4

1

1
兔
Compatible Secondaries
克隆类型
289

124
多克隆
标记
184

27

24

19

18

12

8

8

8

8

8

8

8

8

8

8

5

5

5

5

5

5

2

2

2

2

2

2

2

2

1

1

1

1
This Bcl-2 antibody is un-conjugated
应用范围
312

167

136

100

89

89

74

59

51

31

23

21

18

7

6

5

5

4

2

2

1

1

1

1

1

1

1
Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

原理

Anti-Bcl-2/BCL2 Antibody Picoband®

交叉反应（详细）

No cross-reactivity with other proteins.

产品特性

Anti-Bcl-2/BCL2 Antibody Picoband® (ABIN5693065). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

免疫原

E. coli-derived human Bcl-2 recombinant protein (Position: Q118-E165).

亚型

IgG

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anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 2-211) antibody
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anti-B-Cell CLL/lymphoma 2 (BCL2) antibody
BCL2 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated

anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 2-211) antibody
BCL2 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal D1 unconjugated

anti-B-Cell CLL/lymphoma 2 (BCL2) antibody
BCL2 适用: 人 WB, IHC, StM 宿主: 兔 Monoclonal BCL2-2210R unconjugated Recombinant Antibody

anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 41-54) antibody
BCL2 适用: 人 WB, IHC, FACS, IF, StM, ISt 宿主: 小鼠 Monoclonal 100-D5 unconjugated

anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 1-211) antibody
BCL2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 75-110) antibody
BCL2 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB04684 unconjugated

anti-B-Cell CLL/lymphoma 2 (BCL2) (AA 75-110) antibody
BCL2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

应用备注

Western blot, 0.1-0.5 μg/mL, Human
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
1. Hockenbery, D., Nunez, G., Milliman, C., Schreiber, R. D., Korsmeyer, S. J. : Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 348: 334-336, 1990. 2. Ngan, B.-Y., Chen-Levy, Z., Weiss, L. M., Warnke, R. A., Cleary, M. L. : Expression in non-Hodgkin's lymphoma of the BCL-2 protein associated with the t(14,18) chromosomal translocation. New Eng. J. Med. 318: 1638-1644, 1988.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

储存条件

4 °C,-20 °C

储存方法

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
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Feng, Yan, Zhou, Liang, Liang, Zhao, Dong, Ling: "Piwil2 is reactivated by HPV oncoproteins and initiates cell reprogramming via epigenetic regulation during cervical cancer tumorigenesis." in: Oncotarget, Vol. 7, Issue 40, pp. 64575-64588, (2018) (PubMed).

Guo, Lin, Shao, Rong, Zhang: "BMP‑7 suppresses excessive scar formation by activating the BMP‑7/Smad1/5/8 signaling pathway." in: Molecular medicine reports, Vol. 16, Issue 2, pp. 1957-1963, (2018) (PubMed).

Chen, Zhu, Yang, Wei, Chen, He, Ji: "Ailanthone induces G2/M cell cycle arrest and apoptosis of SGC‑7901 human gastric cancer cells." in: Molecular medicine reports, Vol. 16, Issue 5, pp. 6821-6827, (2018) (PubMed).

Liang, Zhong, Gong, Wang, Zhu, Liu, Yang et al.: "Fibroblast growth factor 21 protects rat cardiomyocytes from endoplasmic reticulum stress by promoting the fibroblast growth factor receptor 1-extracellular signal‑regulated kinase 1/2 signaling ..." in: International journal of molecular medicine, Vol. 40, Issue 5, pp. 1477-1485, (2018) (PubMed).

An, Liu, She, Wu, Tian, Shi, Hao, Ren, Yang, Lu, Yang, Wu: "Replication of hepatitis E virus in the ovary and promotion of oocyte apoptosis in rabbits infected with HEV-4." in: Oncotarget, Vol. 9, Issue 4, pp. 4475-4484, (2018) (PubMed).

Bai, Yang, Luo: "Effects of 5-hydroxy-4'-nitro-7-propionyloxy-genistein on inhibiting proliferation and invasion via activating reactive oxygen species in human ovarian cancer A2780/DDP cells." in: Oncology letters, Vol. 15, Issue 4, pp. 5227-5235, (2018) (PubMed).

Yang, Shi, Soomro, Hu, Du, She: "Hepatitis E Virus Induces Hepatocyte Apoptosis via Mitochondrial Pathway in Mongolian Gerbils." in: Frontiers in microbiology, Vol. 9, pp. 460, (2018) (PubMed).

Wang, Li, Yang, Gao, Lin, Wang, Zhou, Hu: "Ginsenoside Rb1 inhibit apoptosis in rat model of Alzheimer's disease induced by Aβ1-40." in: American journal of translational research, Vol. 10, Issue 3, pp. 796-805, (2018) (PubMed).

Li, Wang, Zhou, Shuang, Zhao, Chen: "Up-Regulation of Long Noncoding RNA SRA Promotes Cell Growth, Inhibits Cell Apoptosis, and Induces Secretion of Estradiol and Progesterone in Ovarian Granular Cells of Mice." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 24, pp. 2384-2390, (2018) (PubMed).

Yang, Wu, Luo, Zhang: "CCAAT/enhancer binding protein homologous protein knockdown alleviates hypoxia-induced myocardial injury in rat cardiomyocytes exposed to high glucose." in: Experimental and therapeutic medicine, Vol. 15, Issue 5, pp. 4213-4222, (2018) (PubMed).

Qi, Xue, Lv, Sun, Du, Cai, Li, Gu, Wang: "Ginkgolic acids induce HepG2 cell death via a combination of apoptosis, autophagy and the mitochondrial pathway." in: Oncology letters, Vol. 15, Issue 5, pp. 6400-6408, (2018) (PubMed).

Zhou, Wang, Xu, Wan, Qu, Fan, Chen, Sun, Liu: "Nek7 is overexpressed in hepatocellular carcinoma and promotes hepatocellular carcinoma cell proliferation in vitro and in vivo." in: Oncotarget, Vol. 7, Issue 14, pp. 18620-30, (2017) (PubMed).

Hu, Sun, Zhang, Zhang, Hu: "Catalpol inhibits apoptosis in hydrogen peroxide-induced cardiac myocytes through a mitochondrial-dependent caspase pathway." in: Bioscience reports, Vol. 36, Issue 3, (2017) (PubMed).

Guo, Wang, Gao, Zhang, Chen, Xu, Hu, Jing, Jing, Li, Wang, Zhu: "Knockdown of High Mobility Group-Box 3 (HMGB3) Expression Inhibits Proliferation, Reduces Migration, and Affects Chemosensitivity in Gastric Cancer Cells." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 22, pp. 3951-3960, (2017) (PubMed).

Hu, Lv, Zhang, Meng: "Comparative Study on the Protective Effects of Salidroside and Hypoxic Preconditioning for Attenuating Anoxia-Induced Apoptosis in Pheochromocytoma (PC12) Cells." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 22, pp. 4082-4091, (2017) (PubMed).

Ustarroz-Cano, Garcia-Pelaez, Cervantes-Yepez, Lopez-Valdez, Fortoul: "Thymic cytoarchitecture changes in mice exposed to vanadium." in: Journal of immunotoxicology, Vol. 14, Issue 1, pp. 9-14, (2017) (PubMed).

Xu, Tan, Jiang, Chen, Lai, Zhang, Liang: "Effects of Bushen Tianjing Recipe in a rat model of tripterygium glycoside-induced premature ovarian failure." in: Chinese medicine, Vol. 12, pp. 10, (2017) (PubMed).

Guo, Liu: "Nogo receptor knockdown and ciliary neurotrophic factor attenuate diabetic retinopathy in streptozotocin-induced diabetic rats." in: Molecular medicine reports, Vol. 16, Issue 2, pp. 2030-2036, (2017) (PubMed).

Shi, Ma, Ren, Liang, Yu, Luo: "Antitumorpharmacological mechanism of the oral liquid of Poriacocos polysaccharide." in: Journal of ethnopharmacology, Vol. 209, pp. 24-31, (2017) (PubMed).

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抗原

Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

别名

BCL2 (BCL2 产品)

背景

Synonyms: Apoptosis regulator Bcl-2, BCL2
Tissue Specificity: Expressed in a variety of tissues.
Background: Immunoreactive BCL2 protein in the neoplastic cells of almost all follicular lymphomas whereas no BCL2 protein was detected in follicles affected by nonneoplastic processes or in normal lymphoid tissue. Every tumor with molecular-genetic evidence of t (14,18) translocation expressed detectable levels of BCL2 protein, regardless of whether the breakpoint was located in or at a distance from the BCL2 gene. Overexpression of BCL2 blocks the apoptotic death of a pro-B-lymphocyte cell line.

分子量

26 kDa

基因ID

596

UniProt

P10415

途径

MAPK Pathway, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling