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Neuroserpin 抗体

SERPINI1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5690556
发货至: 中国
  • 抗原 See all Neuroserpin (SERPINI1) 抗体
    Neuroserpin (SERPINI1) (serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1))
    适用
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    宿主
    • 49
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    克隆类型
    • 54
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    多克隆
    标记
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    This Neuroserpin antibody is un-conjugated
    应用范围
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    Western Blotting (WB), ELISA
    免疫原
    Produced from sera of rabbits pre-immunized with highly pure (>98%) recombinant hNeuroserpin (human Neuroserpin). Human Neuroserpin specific antibody was purified by affinity chromatography employing immobilized hNeuroserpin matrix.
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  • 应用备注
    ELISA:
    Indirect:
    To detect hNeuroserpin by indirect ELISA (using 100 μ,L/well antibody solution) a concentration of 0.5 - 2.0 μ,g/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with compatible secondary reagents, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hNeuroserpin.

    Sandwich
    To detect hNeuroserpin by sandwich ELISA (using 100 μ,L/well antibody solution) a concentration of 0.5 - 2.0 μ,g/mL of this antibody is required. This antigen affinity purified antibody, in conjunction with our biotinylated Anti-Human Neuroserpin as a detection antibody, allows the detection of at least 0.2 - 0.4 ng/well of recombinant hNeuroserpin.

    Western Blot:
    To detect hNeuroserpin by Western Blot analysis this antibody can be used at a concentration of 0.1 - 0.2 μ,g/mL. Used in conjunction with compatible secondary reagents the detection limit for recombinant hNeuroserpin is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.
    限制
    仅限研究用
  • 状态
    Lyophilized
    储存条件
    -20 °C
    储存方法
    Neuroserpin antibody is stable for at least 2 years from date of receipt at -20°C. The reconstituted antibody is stable for at least two weeks at 2-8°C. Frozen aliquots are stable for at least 6 months when stored at -20°C. Avoid repeated freeze-thaw cycles.
  • 抗原
    Neuroserpin (SERPINI1) (serpin Peptidase Inhibitor, Clade I (neuroserpin), Member 1 (SERPINI1))
    别名
    Neuroserpin (SERPINI1 产品)
    别名
    PI12 antibody, neuroserpin antibody, AI837402 antibody, Ns antibody, PI-12 antibody, Spi17 antibody, CG9453 antibody, Dmel\\CG9453 antibody, Serp2 antibody, Sp4 antibody, Spn4 antibody, Spn4A antibody, dSerp2 antibody, sp4 antibody, spn4 antibody, raPIT5a antibody, SERPINI1 antibody, pi12 antibody, serpini1l antibody, si:ch211-167c22.4 antibody, serpin family I member 1 antibody, serine (or cysteine) peptidase inhibitor, clade I, member 1 antibody, Serpin 42Da antibody, serpin peptidase inhibitor, clade I (neuroserpin), member 1 antibody, serpin family I member 1 L homeolog antibody, SERPINI1 antibody, Serpini1 antibody, Spn42Da antibody, serpini1 antibody, serpini1.L antibody
    背景
    Neuroserpin is a member of the serpin superfamily and is predominantly expressed by neurons of the developing and adult brain. This serpin is secreted from axonal growth cones of the CNS and PNS where it inhibits the enzyme tissue plasminogen activator. The expression pattern of neuroserpin and its in vivo inhibitory activity implicate this serpin in regulating axonal growth, reducing seizure activity, controlling damage in cerebral infarction and regulating emotional behaviour and memory. Four different mutations have been described in the human neuroserpin gene that promote neuroserpin abnormal polymerization, giving rise to intraneuronal inclusion bodies and a new form of dementia called Familial Encephalopathy with Neuroserpin Inclusion Bodies.
    基因ID
    5274
    UniProt
    Q99574
    途径
    Regulation of Hormone Metabolic Process
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