KAP1 抗体 (AA 827-831)
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北京 101111
Quick Overview for KAP1 抗体 (AA 827-831) (ABIN5689604)
抗原
See all KAP1 (TRIM28) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 827-831
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特异性
- This antibody detects endogenous level of total TIF1β, protein.
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纯化方法
- Antibodies were purified by affinity-chromatography using epitope-specific peptide.
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免疫原
- TIF1beta antibody was raised against a peptide sequence around aa.827~831 (L-S-G-G-P) derived from Human TIF1β,.
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anti-Tripartite Motif Containing 28 (TRIM28) (AA 576-835) antibody
TRIM28 适用: 人 WB, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) (C-Term) antibodyVerified TRIM28 适用: 人 IHC, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) (AA 379-524) antibodyTRIM28 适用: 人 WB, ELISA, IF, IHC (p), RNAi 宿主: 小鼠 Monoclonal 4E6 unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) antibodyTRIM28 适用: 人 WB, IF, IP, ICC, IHC (p), ChIP 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) (N-Term) antibodyTRIM28 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) (AA 379-524) antibodyTRIM28 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 1D11 unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) (AA 22-291) antibodyTRIM28 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) antibodyTRIM28 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) antibodyTRIM28 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tripartite Motif Containing 28 (TRIM28) (pSer824) antibodyTRIM28 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western Blot: 1:500~1:1000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store antibody at -20°C for up to one year.
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- KAP1 (TRIM28) (Tripartite Motif Containing 28 (TRIM28))
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别名
- TIF1beta
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背景
- Nuclear corepressor for KRAB domain-containing zinc finger proteins (KRAB-ZFPs). Mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 (which specifically methylates histone H3 at 'Lys-9' (H3K9me)) to the promoter regions of KRAB target genes. Enhances transcriptional repression by coordinating the increase in H3K9me, the decrease in histone H3 'Lys-9 and 'Lys-14' acetylation (H3K9ac and H3K14ac, respectively) and the disposition of HP1 proteins to silence gene expression. Recruitment of SETDB1 induces heterochromatinization. May play a role as a coactivator for CEBPB and NR3C1 in the transcriptional activation of ORM1. Also corepressor for ERBB4. Inhibits E2F1 activity by stimulating E2F1-HDAC1 complex formation and inhibiting E2F1 acetylation. May serve as a partial backup to prevent E2F1-mediated apoptosis in the absence of RB1. Important regulator of CDKN1A/p21(CIP1). Has E3 SUMO-protein ligase activity toward itself via its PHD-type zinc finger.
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分子量
- 110 kDa
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基因ID
- 10155
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NCBI登录号
- NP_005753
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UniProt
- Q13263
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途径
- Hedgehog Signaling, Positive Regulation of Response to DNA Damage Stimulus
抗原
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