MAP2K6 抗体 (AA 205-209)
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北京 101111
Quick Overview for MAP2K6 抗体 (AA 205-209) (ABIN5689477)
抗原
See all MAP2K6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 205-209
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特异性
- This antibody detects endogenous level of total MKK6 protein.
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纯化方法
- Antibodies were purified by affinity-chromatography using epitope-specific peptide.
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免疫原
- MKK6 (Ab-207) antibody was raised against a peptide sequence around aa.205~209 (V-D-S-V-A) derived from Human MKK6.
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anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 46-306) antibody
MAP2K6 适用: 人 WB, ELISA, IHC (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) antibodyMAP2K6 适用: 人, 小鼠 WB, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 3H12C8 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 1-334) antibodyMAP2K6 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 231-334) antibodyMAP2K6 适用: 人 WB, ELISA, IF, PLA 宿主: 小鼠 Monoclonal 2F2 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) antibodyMAP2K6 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 3H12B9 unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (pSer207) antibodyMAP2K6 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) antibodyMAP2K6 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (pSer189), (pSer207) antibodyMAP2K6 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (AA 1-334) antibodyMAP2K6 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6) (N-Term) antibodyMAP2K6 适用: 人, 小鼠, 大鼠, Cow, 猴 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store antibody at -20°C for up to one year.
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- MAP2K6 (Mitogen-Activated Protein Kinase Kinase 6 (MAP2K6))
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别名
- MKK6
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背景
- MEK6 is a member of MAPKK protein kinase family. By using degenerate oligonucleotide primers from the conserved kinase domains of MKK3 and MKK4 two human cDNAs and 1 murine cDNA encoding closely related proteins of the MKK family were cloned. The two human clones appear to be different isoforms of the same gene generated by differential splicing: the shorter clone was designated MKK6, encodes a 278-amino acid protein, while the longer clone, designated MKK6b, encodes a 334-amino acid protein. MKK6 is about 80 % identical to MKK3 and 40 % identical to MKK4. 1.7-kb human MKK6 transcript is highly expressed in skeletal muscle, while an MKK6b-specific probe detected mRNA bands of 1.8, 2.4, and 4.5 kb that are enriched in heart, skeletal muscle, pancreas and liver. MKK6 plays an important role in intracellular signaling pathways leading toward activation of the p38 MAP kinase . MEK6 phosphorylates and activates p38 in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAPK mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
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分子量
- 41 kDa
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基因ID
- 5608
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NCBI登录号
- NP_002749
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UniProt
- P52564
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途径
- MAPK Pathway, TLR signaling, Activation of Innate immune Response, Regulation of Muscle Cell Differentiation, Toll-Like Receptors Cascades
抗原
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