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IGF1 抗体 (pTyr1280)

Name: IGF1 抗体 (pTyr1280)
SKU: ABIN5689215
Availability: OutOfStock

IGF1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated

产品编号 ABIN5689215

发货至: 中国

Datasheet as PDF

抗原 See all IGF1 抗体

IGF1 (Insulin-Like Growth Factor 1 (IGF1))
抗原表位
18

15

15

9

8

4

3

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pTyr1280
适用
149

68

60

22

16

9

7

3

2

1
人, 小鼠, 大鼠
宿主
127

50

11

2

1

1
兔
Compatible Secondaries
克隆类型
137

53
多克隆
标记
92

29

13

7

7

5

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This IGF1 antibody is un-conjugated
应用范围
144

76

68

56

41

30

26

26

26

21

15

14

8

8

8

8

7

6

4

2

2

1

1
Western Blotting (WB)

特异性

This antibody detects endogenous levels of IGF-1R only when phosphorylated at tyrosine 1280.

纯化方法

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

免疫原

IGF-1R (Phospho-Tyr1280) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 1280 (S-F-Y (p) -Y-S) derived from Human IGF-1R.

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anti-Insulin-Like Growth Factor 1 (IGF1) (AA 49-118) antibody
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anti-Insulin-Like Growth Factor 1 (IGF1) (AA 49-153) antibody
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anti-Insulin-Like Growth Factor 1 (IGF1) (Internal Region) antibody
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anti-Insulin-Like Growth Factor 1 (IGF1) (AA 115-144) antibody
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anti-Insulin-Like Growth Factor 1 (IGF1) (AA 49-100) antibody
IGF1 适用: 人, 小鼠, 大鼠, 犬 WB, ELISA, IP, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated

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IGF1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) antibody
IGF1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) (AA 115-144), (C-Term) antibody
IGF1 适用: 人 WB, IF, FACS, IHC (p) 宿主: 兔 Polyclonal RB33711 unconjugated

anti-Insulin-Like Growth Factor 1 (IGF1) antibody (HRP)
IGF1 适用: 人 WB, IHC, IF, ICC 宿主: 兔 Polyclonal HRP

应用备注

Western Blot: 1:500~1:1000

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+),  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store antibody at -20°C for up to one year.
抗原

IGF1 (Insulin-Like Growth Factor 1 (IGF1))

别名

IGF 1 (IGF1 产品)

别名

IGF-I antibody, IGF1A antibody, IGFI antibody, C730016P09Rik antibody, Igf-1 antibody, Igf-I antibody, Npt2B antibody, IGF-1 antibody, IGFIA antibody, IGF-IB antibody, igf1 antibody, IGF-1L antibody, IGF-1a antibody, IGF1 antibody, igf-1 antibody, igf1-A antibody, igf1.S antibody, xigf1 antibody, insulin like growth factor 1 antibody, insulin-like growth factor 1 antibody, insulin-like growth factor I antibody, insulin like growth factor 1 L homeolog antibody, IGF1 antibody, Igf1 antibody, LOC100136741 antibody, igf1 antibody, LOC678666 antibody, igf1.L antibody, LOC104911603 antibody

背景

This receptor binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. It has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. When present in a hybrid receptor with INSR, binds IGF1. Ref.19 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, Ref.21 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

分子量

200, 95 kDa

基因ID

3480

NCBI登录号

NP_000866

UniProt

P08069

途径

RTK signaling, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Hormone Activity, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Carbohydrate Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Activated T Cell Proliferation, Positive Regulation of fat Cell Differentiation