Connexin 43/GJA1 抗体 (pSer368)
Quick Overview for Connexin 43/GJA1 抗体 (pSer368) (ABIN5688898)
抗原
See all Connexin 43/GJA1 (GJA1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
 - pSer368
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纯化方法
 - Affinity Purified
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免疫原
 - Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser368 of rat connexin 43.
 
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应用备注
 - The antibody has been directly tested for reactivity in Western blots with rat tissue. It is anticipated that the antibody will react with bovine, canine, chicken, guinea pig, human, mouse and zebra fish based on the fact that these species have 100 % homology with the amino acid sequence used as antigen.
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限制
 - 仅限研究用
 
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状态
 - Liquid
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缓冲液
 - 100 μLin 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.
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储存条件
 - -20 °C
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储存方法
 - Connexin 43 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
 
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- Connexin 43/GJA1 (GJA1) (Gap Junction Protein, alpha 1, 43kDa (GJA1))
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别名
 - Connexin 43
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背景
 - Gap junctional intercellular communication is thought to play a key role in development and may also be involved in epilepsy (Aronica et al., 2001). Connexin 43 forms gap-junctional channels and regulates the permeability of these gap junctions to small organic molecules. Permeability of connexin 43 is known to be regulated by phosphorylation at Ser368 by protein kinase C (Yogo et al., 2002, Bao et al., 2004a). Phosphorylation of Ser368 by PKC induces a conformational change of connexin 43 that results in a decrease in gap junction permeability (Bao et al., 2004b).
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分子量
 - 43 kDa
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基因ID
 - 24392
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UniProt
 - P08050
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途径
 - MAPK Pathway, Myometrial Relaxation and Contraction, Cell-Cell Junction Organization
 
抗原
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