The antibody has been directly tested for reactivity in immunohistochemistry in rat cortex and retinal sections. It is anticipated that the antibody will also work in mouse sections based on the fact that this species has 100 % homology with the amino acid sequence used as antigen.
限制
仅限研究用
状态
Liquid
缓冲液
100 μLin 10 mM HEPES ( pH 7.5), 150 mM NaCl, 100 μg per mL BSA and 50 % glycerol.
储存条件
-20 °C
储存方法
GAT-2 antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
抗原
SLC6A13
(Solute Carrier Family 6 (Neurotransmitter Transporter, GABA), Member 13 (SLC6A13))
GAT3 antibody, Gabt3 antibody, Gat2 antibody, GAT-2 antibody, GAT2 antibody, solute carrier family 6 (neurotransmitter transporter, GABA), member 13 antibody, solute carrier family 6 member 13 antibody, Slc6a13 antibody, SLC6A13 antibody
背景
Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABA plasma membrane transporters (GATs) influence synaptic neurotransmission by high-affinity uptake and release of GABA. To date, four distinct GABA transporters have been identified: GAT-1, GAT-2, GAT-3, and BGT-1. GAT-2 is found in a wide range of neuronal and non-neuronal cells including dendrites and axon terminals as well as epithelial cells and cells forming the pia and arachnoid complex (Conti et al., 1999).