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TARDBP 抗体 (AA 1-260)

Name: TARDBP 抗体 (AA 1-260)
SKU: ABIN565080
Availability: OutOfStock

This anti-TARDBP antibody is a 小鼠单克隆 antibody detecting TARDBP in WB, ELISA, IF, IP, IHC (p) 和 RNAi. Suitable for 人. This Primary Antibody has been cited in 122+ publications.

Western Blot detection against Immunogen (54. (TARDBP 抗体 (AA 1-260))

Immunoperoxidase of monoclonal antibody to TARDBP on formalin-fixed paraffin-embedded human leiomyosarcoma tissue [antibody concentration 3 ug/ml] (TARDBP 抗体 (AA 1-260))

ISt

Immunofluorescence of monoclonal antibody to TARDBP on HeLa cell. (TARDBP 抗体 (AA 1-260))

TARDBP monoclonal antibody (M01), clone 2E2-D3 Western Blot analysis of TARDBP expression in A-431 . (TARDBP 抗体 (AA 1-260))

Western blot analysis of TARDBP over-expressed 293 cell line, cotransfected with TARDBP Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). (TARDBP 抗体 (AA 1-260))

Western Blot analysis of TARDBP expression in transfected 293T cell line by TARDBP monoclonal antibody (M01), clone 2E2-D3. (TARDBP 抗体 (AA 1-260))

Immunoprecipitation of TARDBP transfected lysate using anti-TARDBP monoclonal antibody and Protein A Magnetic Bead , and immunoblotted with TARDBP MaxPab rabbit polyclonal antibody. (TARDBP 抗体 (AA 1-260))

Detection limit for recombinant GST tagged TARDBP is 0. (TARDBP 抗体 (AA 1-260))

ELISA

8 images

(122 references)

产品编号 ABIN565080

发货至: 中国

Datasheet as PDF

Quick Overview for TARDBP 抗体 (AA 1-260) (ABIN565080)

抗原

See all TARDBP 抗体

TARDBP (TAR DNA Binding Protein (TARDBP))

适用

人

宿主

小鼠

克隆类型

单克隆

标记

This TARDBP antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), RNA Interference (RNAi)

克隆位点

2E2-D3

抗原表位
15

8

7

6

6

5

5

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1
AA 1-260

原理

Mouse monoclonal antibody raised against a partial recombinant TARDBP.

序列

MSEYIRVTED ENDEPIEIPS EDDGTVLLST VTAQFPGACG LRYRNPVSQC MRGVRLVEGI LHAPDAGWGN LVYVVNYPKD NKRKMDETDA SSAVKVKRAV QKTSDLIVLG LPWKTTEQDL KEYFSTFGEV LMVQVKKDLK TGHSKGFGFV RFTEYETQVK VMSQRHMIDG RWCDCKLPNS KQSQDEPLRS RKVFVGRCTE DMTEDELREF FSQYGDVMDV FIPKPFRAFA FVTFADDQIA QSLCGEDLII KGISVHISNA

交叉反应

人

产品特性

Antibody Reactive Against Recombinant Protein.

免疫原

TARDBP (NP_031401.1, 1 a.a. ~ 260 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

亚型

IgG1
anti-TAR DNA Binding Protein (TARDBP) (AA 104-262) antibody
TARDBP 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-TAR DNA Binding Protein (TARDBP) (AA 1-260) antibody
TARDBP 适用: 人 WB, IP, RIP 宿主: 兔 Polyclonal unconjugated

anti-TAR DNA Binding Protein (TARDBP) antibody
TARDBP 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated

anti-TAR DNA Binding Protein (TARDBP) antibody
TARDBP 适用: 人 WB, IHC, ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 6G2D8 unconjugated

anti-TAR DNA Binding Protein (TARDBP) (C-Term) antibody
TARDBP 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-TAR DNA Binding Protein (TARDBP) antibody
KO Validated TARDBP 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-TAR DNA Binding Protein (TARDBP) (N-Term) antibody
TARDBP 适用: 人, 小鼠, 大鼠, 犬, Cow, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-TAR DNA Binding Protein (TARDBP) (AA 1-396) antibody
TARDBP 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-TAR DNA Binding Protein (TARDBP) (AA 1-261) antibody
TARDBP 适用: 人 WB, IHC, ELISA, IF, IHC (p), RNAi 宿主: 小鼠 Monoclonal 2E2-D3 unconjugated

anti-TAR DNA Binding Protein (TARDBP) (AA 126-260) antibody
TARDBP 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 7F9A6 unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
缓冲液

In 1x PBS, pH 7.4

注意事项

Aliquot to avoid repeated freezing and thawing.

储存条件

-20 °C

储存方法

Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Lynch, Jaunmuktane, Sheerin, Phadke, Brandner, Milonas, Dean, Bajaj, McNicholas, Costello, Cronin, McGuigan, Rossor, Fox, Murphy, Chataway, Houlden: "Hereditary leukoencephalopathy with axonal spheroids: a spectrum of phenotypes from CNS vasculitis to parkinsonism in an adult onset leukodystrophy series." in: Journal of neurology, neurosurgery, and psychiatry, Vol. 87, Issue 5, pp. 512-9, (2016) (PubMed).

De Marco, Lomartire, Calvo, Risso, De Luca, Mostert, Mandrioli, Caponnetto, Borghero, Manera, Canosa, Moglia, Restagno, Fini, Tarella, Giordana, Rinaudo, Chiò: "Monocytes of patients with amyotrophic lateral sclerosis linked to gene mutations display altered TDP-43 subcellular distribution." in: Neuropathology and applied neurobiology, Vol. 43, Issue 2, pp. 133-153, (2016) (PubMed).

Gelpi, Höftberger, Graus, Ling, Holton, Dawson, Popovic, Pretnar-Oblak, Högl, Schmutzhard, Poewe, Ricken, Santamaria, Dalmau, Budka, Revesz, Kovacs: "Neuropathological criteria of anti-IgLON5-related tauopathy." in: Acta neuropathologica, Vol. 132, Issue 4, pp. 531-43, (2016) (PubMed).

Rosenbohm, Buckert, Gerischer, Walcher, Kassubek, Rottbauer, Ludolph, Bernhardt: "Early diagnosis of cardiac involvement in idiopathic inflammatory myopathy by cardiac magnetic resonance tomography." in: Journal of neurology, Vol. 262, Issue 4, pp. 949-56, (2015) (PubMed).

Iovino, Pfisterer, Holton, Lashley, Swingler, Calo, Treacy, Revesz, Parmar, Goedert, Muqit, Spillantini: "The novel MAPT mutation K298E: mechanisms of mutant tau toxicity, brain pathology and tau expression in induced fibroblast-derived neurons." in: Acta neuropathologica, Vol. 127, Issue 2, pp. 283-95, (2014) (PubMed).

Hebron, Chen, Miessau, Lonskaya, Moussa: "Parkin reverses TDP-43-induced cell death and failure of amino acid homeostasis." in: Journal of neurochemistry, Vol. 129, Issue 2, pp. 350-61, (2014) (PubMed).

Suárez-Calvet, Dols-Icardo, Lladó, Sánchez-Valle, Hernández, Amer, Antón-Aguirre, Alcolea, Fortea, Ferrer, van der Zee, Dillen, Van Broeckhoven, Molinuevo, Blesa, Clarimón, Lleó: "Plasma phosphorylated TDP-43 levels are elevated in patients with frontotemporal dementia carrying a C9orf72 repeat expansion or a GRN mutation." in: Journal of neurology, neurosurgery, and psychiatry, Vol. 85, Issue 6, pp. 684-91, (2014) (PubMed).

Yan, Wang, Wei, Gaertig, Lai, Li, Li: "TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain." in: Human molecular genetics, Vol. 23, Issue 10, pp. 2678-93, (2014) (PubMed).

De Marco, Lomartire, Mandili, Lupino, Buccinnà, Ramondetti, Moglia, Novelli, Piccinini, Mostert, Rinaudo, Chiò, Calvo: "Reduced cellular Ca(2+) availability enhances TDP-43 cleavage by apoptotic caspases." in: Biochimica et biophysica acta, Vol. 1843, Issue 4, pp. 725-34, (2014) (PubMed).

Cortese, Plagnol, Brady, Simone, Lashley, Acevedo-Arozena, de Silva, Greensmith, Holton, Hanna, Fisher, Fratta: "Widespread RNA metabolism impairment in sporadic inclusion body myositis TDP43-proteinopathy." in: Neurobiology of aging, Vol. 35, Issue 6, pp. 1491-8, (2014) (PubMed).

Ohta, Tremblay, Schneider, Bennett, Calon, Julien: "Interaction of transactive response DNA binding protein 43 with nuclear factor ?B in mild cognitive impairment with episodic memory deficits." in: Acta neuropathologica communications, Vol. 2, Issue 1, pp. 37, (2014) (PubMed).

Gelpi, Navarro-Otano, Tolosa, Gaig, Compta, Rey, Martí, Hernández, Valldeoriola, Reñé, Ribalta: "Multiple organ involvement by alpha-synuclein pathology in Lewy body disorders." in: Movement disorders : official journal of the Movement Disorder Society, Vol. 29, Issue 8, pp. 1010-8, (2014) (PubMed).

Carlomagno, Zhang, Davis, Lin, Cook, Dunmore, Tay, Menkosky, Cao, Petrucelli, Deture: "Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins." in: PLoS ONE, Vol. 9, Issue 3, pp. e90452, (2014) (PubMed).

Kara, Kiely, Proukakis, Giffin, Love, Hehir, Rantell, Pandraud, Hernandez, Nacheva, Pittman, Nalls, Singleton, Revesz, Bhatia, Quinn, Hardy, Holton, Houlden: "A 6.4 Mb duplication of the ?-synuclein locus causing frontotemporal dementia and Parkinsonism: phenotype-genotype correlations." in: JAMA neurology, Vol. 71, Issue 9, pp. 1162-71, (2014) (PubMed).

Balasa, Gelpi, Rey, Vila, Ramió-Torrentà, Quiles Granado, Molina Latorre, Lepidi, Raoult, Saiz: "Clinical and neuropathological variability in clinically isolated central nervous system Whipple's disease." in: Brain pathology (Zurich, Switzerland), Vol. 24, Issue 3, pp. 230-8, (2014) (PubMed).

Araki, Minegishi, Motoki, Kume, Hohjoh, Araki, Tamaoka: "Disease-associated mutations of TDP-43 promote turnover of the protein through the proteasomal pathway." in: Molecular neurobiology, Vol. 50, Issue 3, pp. 1049-58, (2014) (PubMed).

Hans, Fiesel, Strong, Jäckel, Rasse, Geisler, Springer, Schulz, Voigt, Kahle: "UBE2E ubiquitin-conjugating enzymes and ubiquitin isopeptidase Y regulate TDP-43 protein ubiquitination." in: The Journal of biological chemistry, Vol. 289, Issue 27, pp. 19164-79, (2014) (PubMed).

Robinson, Thompson, Weedon, Rollinson, Pickering-Brown, Snowden, Davidson, Mann: "No interaction between tau and TDP-43 pathologies in either frontotemporal lobar degeneration or motor neurone disease." in: Neuropathology and applied neurobiology, Vol. 40, Issue 7, pp. 844-54, (2014) (PubMed).

Alafuzoff, Pikkarainen, Neumann, Arzberger, Al-Sarraj, Bodi, Bogdanovic, Bugiani, Ferrer, Gelpi, Gentleman, Giaccone, Graeber, Hortobagyi, Ince, Ironside, Kavantzas, King, Korkolopoulou, Kovács et al.: "Neuropathological assessments of the pathology in frontotemporal lobar degeneration with TDP43-positive inclusions: an inter-laboratory study by the BrainNet Europe consortium. ..." in: Journal of neural transmission (Vienna, Austria : 1996), (2014) (PubMed).

Wenqiang, Lonskaya, Hebron, Ibrahim, Olszewski, Neale, Moussa: "Parkin-mediated reduction of nuclear and soluble TDP-43 reverses behavioral decline in symptomatic mice." in: Human molecular genetics, Vol. 23, Issue 18, pp. 4960-9, (2014) (PubMed).

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抗原

TARDBP (TAR DNA Binding Protein (TARDBP))

别名

TARDBP

背景

Full Gene Name: TAR DNA binding protein
Synonyms: ALS10,TDP-43

基因ID

23435

NCBI登录号

NM_007375

途径

Positive Regulation of Peptide Hormone Secretion