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R-Spondin 3 抗体 (AA 214-248)

RSPO3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5647910
发货至: 中国
  • 抗原 See all R-Spondin 3 (RSPO3) 抗体
    R-Spondin 3 (RSPO3)
    抗原表位
    • 9
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 214-248
    适用
    • 24
    • 9
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 19
    • 2
    • 2
    • 2
    • 1
    克隆类型
    • 22
    • 4
    多克隆
    标记
    • 20
    • 2
    • 2
    • 2
    This R-Spondin 3 antibody is un-conjugated
    应用范围
    • 19
    • 13
    • 7
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB)
    纯化方法
    Antigen affinity purified
    免疫原
    A portion of amino acids 214-248 from the human protein was used as the immunogen for the RSPO3 antibody.
    亚型
    Ig Fraction
    Top Product
    Discover our top product RSPO3 Primary Antibody
  • 应用备注
    Western blot: 1:1000-2000
    限制
    仅限研究用
  • 缓冲液
    In 1X PBS, pH 7.4, with 0.09 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Aliquot the RSPO3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • 抗原
    R-Spondin 3 (RSPO3)
    别名
    RSPO3 / R-spondin 3 (RSPO3 产品)
    别名
    pwtsr antibody, thsd2 antibody, cristin1 antibody, CRISTIN1 antibody, PWTSR antibody, THSD2 antibody, RGD1563246 antibody, 2810459H04Rik antibody, AW742308 antibody, Cristin1 antibody, Thsd2 antibody, R-spondin 3 antibody, rspo3 antibody, RSPO3 antibody, Rspo3 antibody
    背景
    R-spondin-3 is an activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.
    基因ID
    84870
    UniProt
    Q9BXY4
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