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APAF1 抗体 (C-Term)
APAF1
适用: 人, 小鼠, 大鼠
IHC (p)
宿主: 兔
Polyclonal
unconjugated
APAF1抗体详情
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抗原
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APAF1
(Apoptotic Peptidase Activating Factor 1 (APAF1))
抗原表位
All epitopes for APAF1 抗体
C-Term
适用
All reactivities for APAF1 抗体
人, 小鼠, 大鼠
宿主
All hosts for APAF1 抗体
兔
克隆类型
All clonalities for APAF1 抗体
多克隆
标记
All conjugates for APAF1 抗体
This APAF1 antibody is un-conjugated
应用范围
All applications for APAF1 抗体
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
特异性
This antibody reacts to Apoptotic Protease Activating Factor 1 (APAF1).
纯化方法
Immunoaffinity Chromatography
免疫原
APAF1 antibody was raised against a synthetic peptide derived from the C-terminus of human Apaf-1 Genename: APAF1
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Discover our top product APAF1 Primary Antibody
Alternatives
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使用细节
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应用备注
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
贮存及处理
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缓冲液
10 mM PBS, pH 7.4, BSA, sodium azide.
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
4 °C
储存方法
Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!
APAF1目标详情
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抗原
APAF1
(Apoptotic Peptidase Activating Factor 1 (APAF1))
别名
APAF1 (APAF1 产品 )
别名
APAF1 antibody, ARK antibody, Apaf-1 antibody, Apaf1 antibody, CG6829 antibody, D-Apaf-1 antibody, DARK antibody, Dapaf-1 antibody, Dapaf-1/HAC-1 antibody, Dark antibody, Dark/Apaf-I antibody, Dark/Dapaf-1/HAC1 antibody, Dark/Hac-1/dApaf-1 antibody, Dark/Hac-1/dApaf1 antibody, Dmel\\CG6829 antibody, Hac-1 antibody, Hac-1/Dark antibody, Hac1 antibody, T1 antibody, anon-53Fa antibody, apaf-1 antibody, apaf1 antibody, arc antibody, ark antibody, dAPAF-1 antibody, dApaf-1 antibody, dApaf-1/DARK/HAC-1 antibody, dApaf1 antibody, dArk antibody, dapaf antibody, dapaf-1 antibody, dapaf-1L antibody, dapaf-1S antibody, dark antibody, dark/dapaf-1/hac-1 antibody, dark/hac-1/dapaf-1 antibody, hac-1 antibody, hac1 antibody, l(2)SH0173 antibody, APAF-1 antibody, CED4 antibody, 6230400I06Rik antibody, Apaf1l antibody, fog antibody, mKIAA0413 antibody, zgc:136543 antibody, Death-associated APAF1-related killer antibody, apoptotic peptidase activating factor 1 L homeolog antibody, apoptotic peptidase activating factor 1 antibody, Dark antibody, apaf1.L antibody, apaf1 antibody, APAF1 antibody, Apaf1 antibody
背景
Apaf1 has been described as the core of the apoptosome. Deficiency in murine Apaf1 leads to embryonic lethality with a phenotype affecting many aspects of developmental apoptosis. In the developing brain, Apaf1 is a death regulator of the neuronal founder cells. Combined intercrosses of mouse lines mutant for members of the mitochondrial death pathway are providing us with some clues about the relative regulation existing among neuronal cell populations. Apaf1-deficient embryos display an interesting phenotype in the inner ear and in limb development, which involves different caspase-dependent and -independent pathways. Moreover, APAF1 is mutated in human melanomas, and its depletion contributes to malignant transformation in a mouse model of cancer.Synonyms: Apaf-1, Apoptotic protease-activating factor 1, KIAA0413
基因ID
317
NCBI登录号
NP_001151
UniProt
O14727
途径
p53 Pathway , Apoptosis , Caspase Cascade in Apoptosis , Tube Formation , Positive Regulation of Endopeptidase Activity
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