eIF4EBP1 抗体 (pSer65)
Quick Overview for eIF4EBP1 抗体 (pSer65) (ABIN5611114)
抗原
See all eIF4EBP1 (EIF4EBP1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pSer65
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原理
- Phospho-4E-BP1 (Ser65) Antibody
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纯化方法
- Purified antibody
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免疫原
- Synthesized peptide of human Phospho-4E-BP1 (Ser65).
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亚型
- IgG1
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应用备注
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/100 - 1/500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Purified antibody in PBS with 0.05 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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- eIF4EBP1 (EIF4EBP1) (Eukaryotic Translation Initiation Factor 4E Binding Protein 1 (EIF4EBP1))
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别名
- 4E-BP1
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背景
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This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.
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分子量
- 12.6 kDa
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基因ID
- 1978
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UniProt
- Q13541
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途径
- MAPK Pathway, PI3K-Akt Signaling, RTK signaling, AMPK Signaling, Regulation of Cell Size, BCR Signaling
抗原
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