c-MET 抗体
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北京 101111
Quick Overview for c-MET 抗体 (ABIN5542211)
抗原
See all c-MET (MET) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Recognizes c-Met. Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells.
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纯化方法
- Affinity Chromatography on Protein G
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免疫原
- cDNA encoding Human c-Met
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亚型
- IgG2b
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应用备注
- Flow Cytometry: 1.2 μg/10 6 cells. Cell based ELISA with intakt, transiently transfected cells: 1/200-1/400.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS, pH 7.2
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储存条件
- 4 °C,-20 °C
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储存方法
- Store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
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有效期
- 12 months
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- c-MET (MET) (Met Proto-Oncogene (MET))
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别名
- hgf receptor
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背景
- C-MET is a receptor tyrosine kinase that is activated upon Hepatocyte Growth Factor (HGF) binding. c-MET is produced as a single-chain precursor and plays en essential role in embryonic development and wound healing. It belongs to the class of Singlepass type I membrane proteins and it is normally expressed by cells of epithelial origin while the expression of HGF is restricted to cells of mesenchymal origin in an almost perfect paracrine paradigm. Overexpression of c-MET can be found in several kinds of tumor progression.
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UniProt
- P08581
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途径
- RTK signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor
抗原
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