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- 抗原 See all KIR2DS1 抗体
- KIR2DS1 (Killer Cell Immunoglobulin Like Receptor 2DS1 (KIR2DS1))
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抗原表位
- AA 151-180
- 适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This KIR2DS1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- 免疫原
- This KIR2DS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from the Central region of human KIR2DS1.
- 亚型
- Ig Fraction
- Top Product
- Discover our top product KIR2DS1 Primary Antibody
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- 应用备注
- For WB starting dilution is: 1:1000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 mg/mL
- 缓冲液
- Supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- KIR2DS1 (Killer Cell Immunoglobulin Like Receptor 2DS1 (KIR2DS1))
- 别名
- KIR2DS1 (KIR2DS1 产品)
- 别名
- CD158H antibody, CD158a antibody, p50.1 antibody, killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 antibody, KIR2DS1 antibody
- 背景
- Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.
- 分子量
- 34 kDa
- 基因ID
- 3806
- UniProt
- Q14954
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