HCAR2 抗体 (AA 200-228)
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北京 101111
Quick Overview for HCAR2 抗体 (AA 200-228) (ABIN5536145)
抗原
See all HCAR2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 200-228
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纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
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免疫原
- This NIACR1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-228 amino acids from the Central region of human NIACR1.
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亚型
- Ig Fraction
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anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) (AA 82-94), (Extracellular) antibody
HCAR2 适用: 小鼠 IHC, WB, FACS, LCI 宿主: 兔 Polyclonal unconjugated
anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) (AA 250-350) antibodyHCAR2 适用: 人 IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) antibodyHCAR2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Hydroxycarboxylic Acid Receptor 2 (HCAR2) (AA 82-94), (Extracellular) antibody (FITC)HCAR2 适用: 小鼠 FACS, LCI 宿主: 兔 Polyclonal FITC
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应用备注
- For WB starting dilution is: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Supplied in PBS with 0.09 % (W/V) sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- HCAR2 (Hydroxycarboxylic Acid Receptor 2 (HCAR2))
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别名
- NIACR1
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背景
- NIACR1 acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis. The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.
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分子量
- 42 kDa
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基因ID
- 338442
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UniProt
- Q8TDS4
抗原
-
