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- 抗原 See all HTRA3 抗体
- HTRA3 (HtrA Serine Peptidase 3 (HTRA3))
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抗原表位
- AA 112-144, N-Term
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适用
- 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This HTRA3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
- 免疫原
- This HtrA3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 112-144 amino acids from the N-terminal region of human HtrA3.
- 亚型
- Ig Fraction
- Top Product
- Discover our top product HTRA3 Primary Antibody
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anti-HtrA Serine Peptidase 3 (HTRA3) (AA 112-144), (N-Term) antibody
HTRA3 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB2322 unconjugated
anti-HtrA Serine Peptidase 3 (HTRA3) (AA 344-453) antibodyHTRA3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1F2 unconjugated
anti-HtrA Serine Peptidase 3 (HTRA3) antibodyHTRA3 适用: 人, 大鼠, 小鼠 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 3 (HTRA3) (AA 250-300) antibodyHTRA3 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 3 (HTRA3) (AA 214-453) antibodyHTRA3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 3 (HTRA3) (AA 334-453) antibodyHTRA3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-HtrA Serine Peptidase 3 (HTRA3) antibodyHTRA3 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 2 mg/mL
- 缓冲液
- Supplied in PBS with 0.09 % (W/V) sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- HTRA3 (HtrA Serine Peptidase 3 (HTRA3))
- 别名
- HtrA3 (HTRA3 产品)
- 别名
- HTRA3 antibody, Prsp antibody, Tasp antibody, 2210021K23Rik antibody, 9530081K03Rik antibody, RGD1308120 antibody, Trypsin-like serine protease antibody, HtrA serine peptidase 3 antibody, htrA3 antibody, HTRA3 antibody, Htra3 antibody
- 背景
- Insulin-like growth factors (IGFs) stimulate the proliferation and differentiation of a vast number of cell types. The action of the growth factors is mediated and controlled by a complex system of components, including several proteases that cleave the IGF-Binding Proteins. HtrA1 is a 480 aa protein that contains an N-terminus homologous to MAC25 (IGFBP7) with a conserved Kazal-type serine protease inhibitor motif, as well as a C-terminal PDZ domain. Semiquantitative RT-PCR and immunoblot analyses showed an approximately 7-fold increase of PRSS11 in osteoarthritis cartilage compared with controls. HTRA2 is released from mitochondria and inhibits the function of XIAP by direct binding in a way similar to SMAC. Moreover, when overexpressed extramitochondrially, HTRA2 induced atypical cell death, which was neither accompanied by a significant increase in caspase activity nor inhibited by caspase inhibitors, including XIAP. A catalytically inactive mutant of HTRA2, however, did not induce cell death. Suzuki et al. (2001) concluded that HTRA2 is a SMAC-like inhibitor of IAP (inhibitor of apoptosis proteins) activity with a serine protease-dependent cell death-inducing activity.
- 分子量
- 49 kDa
- 基因ID
- 94031
- UniProt
- P83110
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