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COL1A1 抗体 (C-Term)

Name: COL1A1 抗体 (C-Term)
SKU: ABIN5518708
Availability: OutOfStock

COL1A1 适用: 人, 大鼠, 小鼠 WB, ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

Anti-Collagen I antibody, IHC(F): Human Placenta Tissue

IHC

Anti-Collagen I antibody, ICC: NIH3T3 Cell

Anti-Collagen I antibody, IHC(P): Human Intestinal Cancer Tissue

IHC

Anti-Collagen I antibody, IHC(P): Rat Lung Tissue

IHC

Anti-Collagen I antibody, Western blotting Lane 1: Rat Lung Tissue Lysate Lane 2: Human Placenta Tissue Lysate Lane 3: Rat Testis Tissue Lysate

5 images

(74 references)

产品编号 ABIN5518708

发货至: 中国

Datasheet as PDF

抗原 See all COL1A1 抗体

COL1A1 (Collagen, Type I, alpha 1 (COL1A1))
抗原表位
12

9

6

4

4

4

3

2

2

2

1

1

1

1

1

1

1

1
AA 1192-1207, C-Term
适用
57

29

24

12

5

4

4

3

2

2

2

2

1

1

1

1
人, 大鼠, 小鼠
宿主
66

12
兔
Compatible Secondaries
克隆类型
57

21
多克隆
标记
41

9

7

5

2

2

2

2

2

2

2

2
This COL1A1 antibody is un-conjugated
应用范围
51

36

34

10

9

9

7

3

3

2

1
Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

原理

Rabbit IgG polyclonal antibody for Collagen alpha-1(I) chain(COL1A1) detection. Tested with WB, IHC-P, IHC-F, ICC in Human,Mouse,Rat.

序列

QPPQEKSQDG GRYYRA

交叉反应（详细）

No cross reactivity with other proteins.

产品特性

Rabbit IgG polyclonal antibody for Collagen alpha-1(I) chain(COL1A1) detection. Tested with WB, IHC-P, IHC-F, ICC in Human,Mouse,Rat.
Gene Name: collagen, type I, alpha 1
Protein Name: Collagen alpha-1(I) chain

纯化方法

Immunogen affinity purified.

免疫原

A synthetic peptide corresponding to a sequence at the C-terminus of mouse Collagen I(1192-1207aa QPPQEKSQDGGRYYRA), identical to the related rat sequence, and different from the related human sequence by two amino acids.

亚型

IgG
anti-Collagen, Type I, alpha 1 (COL1A1) (AA 253-471) antibody
COL1A1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Collagen, Type I, alpha 1 (COL1A1) (AA 1225-1453) antibody
COL1A1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Collagen, Type I, alpha 1 (COL1A1) (AA 1218-1440) antibody
COL1A1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C3 unconjugated

anti-Collagen, Type I, alpha 1 (COL1A1) (AA 253-471) antibody
COL1A1 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C5 unconjugated

anti-Collagen, Type I, alpha 1 (COL1A1) antibody
COL1A1 适用: 人, 大鼠, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Collagen, Type I, alpha 1 (COL1A1) (AA 100-200) antibody
COL1A1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Collagen, Type I, alpha 1 (COL1A1) (AA 1021-1108) antibody
COL1A1 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3G3 unconjugated

anti-Collagen, Type I, alpha 1 (COL1A1) (AA 1219-1464) antibody
COL1A1 适用: 人 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 7B1G12 unconjugated

anti-Collagen, Type I, alpha 1 (COL1A1) (AA 521-680) antibody
COL1A1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Collagen, Type I, alpha 1 (COL1A1) antibody
COL1A1 适用: 人 IHC, ELISA 宿主: 小鼠 Monoclonal unconjugated

应用备注

WB: Concentration: 0.1-0.5 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, The detection limit for COL1A1 is approximately 0.5 ng/lane under reducing conditions.
IHC-P: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse, Epitope Retrieval by Heat: Boiling the paraffin sections in 10 mM citrate buffer, pH 6.0, for 20 mins is required for the staining of formalin/paraffin sections.
IHC-F: Concentration: 0.5-1 μg/mL, Tested Species: Human, Rat, Predicted Species: Mouse
ICC: Concentration: 0.5-1 μg/mL, Tested Species: Mouse, Predicted Species: Human, Rat
Notes: Tested Species: Species with positive results. Predicted Species: Species predicted to be fit for the product based on sequence similarities. Other applications have not been tested. Optimal dilutions should be determined by end users.

说明

Antibody can be supported by chemiluminescence kit ABIN921124 in WB, supported by ABIN921231 in IHC(P), IHC(F) and ICC.

限制

仅限研究用
状态

Lyophilized

溶解方式

Add 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

浓度

500 μg/mL

缓冲液

Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

储存液

Sodium azide, Thimerosal (Merthiolate)

注意事项

This product contains Sodium azide and Thimerosal (Merthiolate): POISONOUS AND HAZARDOUS SUBSTANCES which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

At -20°C for one year. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20 °C for a longer time. Avoid repeated freezing and thawing.
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"Retraction: Naringin Alleviates Diabetic Kidney Disease through Inhibiting Oxidative Stress and Inflammatory Reaction." in: PLoS ONE, Vol. 13, Issue 2, pp. e0192465, (2018) (PubMed).

Jiang, Zhong, Zheng, Zhao: "Nano-hydroxyapatite/collagen film as a favorable substrate to maintain the phenotype and promote the growth of chondrocytes cultured in vitro." in: International journal of molecular medicine, Vol. 41, Issue 4, pp. 2150-2158, (2018) (PubMed).

Zhang, Ju, Nie, Song, Xu, Gao: "Adenovirus‑mediated knockdown of activin A receptor type 2A attenuates immune‑induced hepatic fibrosis in mice and inhibits interleukin‑17‑induced activation of primary hepatic stellate cells." in: International journal of molecular medicine, Vol. 42, Issue 1, pp. 279-289, (2018) (PubMed).

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Cheng, Ge, Lan, Ma, Chi, Kuang, Sun, Zhao, Liu, Feng, Huang, Luo, Li, Zhang, Hu, Xu, Liu, Huo, Deng, Yang, Xi, Zhang, Siegenthaler, Chen: "Zoledronate dysregulates fatty acid metabolism in renal tubular epithelial cells to induce nephrotoxicity." in: Archives of toxicology, Vol. 92, Issue 1, pp. 469-485, (2017) (PubMed).

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抗原

COL1A1 (Collagen, Type I, alpha 1 (COL1A1))

别名

COL1A1 (COL1A1 产品)

别名

OI4 antibody, Col1a-1 antibody, Cola-1 antibody, Cola1 antibody, Mov-13 antibody, Mov13 antibody, COLIA1 antibody, col1a1 antibody, MGC52532 antibody, COL1A1 antibody, COL1A2 antibody, alpha1(I) antibody, cb21 antibody, sb:cb21 antibody, sb:cb384 antibody, wu:fa99c12 antibody, wu:fb02c06 antibody, alpha3(I) antibody, col1a3 antibody, hm:zeh0348 antibody, wu:fa95h05 antibody, wu:fd02a10 antibody, wu:fj59a10 antibody, collagen type I alpha 1 chain antibody, collagen, type I, alpha 1 antibody, collagen, type I, alpha 1 S homeolog antibody, collagen alpha-1(I) chain antibody, collagen type I alpha 2 chain antibody, collagen, type I, alpha 1a antibody, collagen 1a1 antibody, collagen, type I, alpha 1b antibody, COL1A1 antibody, Col1a1 antibody, col1a1.S antibody, LOC397571 antibody, COL1A2 antibody, col1a1a antibody, col1a1 antibody, col1a1b antibody

背景

Collagen, type I, alpha 1, also known as COL1A1, is a human gene that encodes the major component of type I collagen, the fibrillar collagen found in most connective tissues, including cartilage. This gene is mapped to 17q21.33. This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis.

Synonyms: Alpha 1 type I collagen antibody|Alpha 2 type I collagen antibody|Alpha-1 type I collagen antibody|CO1A1_HUMAN antibody|COL1A1 antibody|COL1A2 antibody|Collagen alpha-1(I) chain antibody|Collagen I alpha 1 polypeptide antibody|Collagen I alpha 2 polypeptide antibody|Collagen Of Skin Tendon And Bone antibody|Collagen Type 1 antibody|Collagen type I alpha 1 antibody|Collagen type I alpha 2 antibody|OI4 antibody|Osteogenesis Imperfecta Type IV antibody|Pro alpha 1(I) collagen antibody|Type I procollagen antibody

UniProt

P11087

途径

Sensory Perception of Sound, Autophagy, Growth Factor Binding