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WDR48 抗体 (C-Term)

WDR48 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5517646
发货至: 中国
  • 抗原 See all WDR48 抗体
    WDR48 (WD Repeat Domain 48 (WDR48))
    抗原表位
    • 10
    • 10
    • 7
    • 1
    C-Term
    适用
    • 21
    • 4
    • 3
    宿主
    • 22
    克隆类型
    • 22
    多克隆
    标记
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    This WDR48 antibody is un-conjugated
    应用范围
    • 20
    • 17
    • 15
    • 13
    • 5
    • 1
    • 1
    Western Blotting (WB)
    序列
    NESQTTSSSN NEKPGEQEKE EDIAVLAEEK IELLCQDQVL DPNMDLRTVK
    纯化方法
    Affinity purified
    免疫原
    The immunogen is a synthetic peptide directed towards the C terminal region of human WDR48
    Top Product
    Discover our top product WDR48 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    WDR48 (WD Repeat Domain 48 (WDR48))
    别名
    WDR48 (WDR48 产品)
    别名
    P80 antibody, UAF1 antibody, 8430408H12Rik antibody, mKIAA1449 antibody, WD repeat domain 48 antibody, WDR48 antibody, Wdr48 antibody
    背景
    Regulator of deubiquitinating complexes. Acts as a strong activator of USP1 and USP46. Enhances the USP1-mediated deubiquitination of FANCD2, USP1 being almost inactive by itself. Also activates deubiquitinating activity of complexes containing USP12. Activates deubiquitination by increasing the catalytic turnover without increasing the affinity of deubiquitinating enzymes for the substrate. In case of infection by Herpesvirus saimiri, may play a role in vesicular transport or membrane fusion events necessary for transport to lysosomes. Induces lysosomal vesicle formation via interaction with Herpesvirus saimiri tyrosine kinase-interacting protein (TIP). Subsequently, TIP recruits tyrosine-protein kinase LCK, resulting in down-regulation of T-cell antigen receptor TCR. May play a role in generation of enlarged endosomal vesicles via interaction with TIP. In case of infection by papillomavirus HPV11, promotes the maintenance of the viral genome via its interaction with HPV11 helicase E1.

    Alias Symbols: P80, UAF1, SPG60

    Protein Size: 677
    基因ID
    57599
    NCBI登录号
    NM_001303402, NP_001290331
    UniProt
    Q8TAF3
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