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SLAMF7 抗体 (Middle Region)

SLAMF7 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN5516380
发货至: 中国
  • 抗原 See all SLAMF7 抗体
    SLAMF7 (SLAM Family Member 7 (SLAMF7))
    抗原表位
    • 16
    • 7
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Middle Region
    适用
    • 39
    • 23
    • 3
    宿主
    • 31
    • 9
    • 3
    克隆类型
    • 34
    • 9
    多克隆
    标记
    • 23
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SLAMF7 antibody is un-conjugated
    应用范围
    • 36
    • 18
    • 16
    • 9
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    序列
    QNRNRERVDF PDGGYSLKLS KLKKNDSGIY YVGIYSSSLQ QPSTQEYVLH
    纯化方法
    Affinity purified
    免疫原
    The immunogen is a synthetic peptide directed towards the middle region of human SLAMF7
    Top Product
    Discover our top product SLAMF7 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • 抗原
    SLAMF7 (SLAM Family Member 7 (SLAMF7))
    别名
    SLAMF7 (SLAMF7 产品)
    别名
    RGD1560190 antibody, SLAMF7 antibody, slaf7 antibody, 19A antibody, CD319 antibody, CRACC antibody, CS1 antibody, 19A24 antibody, 4930560D03Rik antibody, SLAM family member 7 antibody, Slamf7 antibody, SLAMF7 antibody, slaf7 antibody
    背景
    Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K. In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells. May play a role in lymphocyte adhesion. In LPS-activated monocytes negatively regulates production of proinflammatory cytokines.

    Alias Symbols: 19A, CS1, CD319, CRACC

    Protein Size: 296
    基因ID
    57823
    NCBI登录号
    NM_001282588, NP_067004
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