MAP2K4 抗体 (C-Term)
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Quick Overview for MAP2K4 抗体 (C-Term) (ABIN7482650)
抗原
See all MAP2K4 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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序列
- NLKIIHRDIK PSNILLDRSG NIKLCDFGIS GQLVDSIAKT RDAGCRPYMA
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产品特性
- This is a rabbit polyclonal antibody against MAP2K4. It was validated on Western Blot.
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免疫原
- The immunogen is a synthetic peptide directed towards the C-terminal region of Human MAP2K4
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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- MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))
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别名
- MAP2K4
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背景
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This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants.
Alias Symbols: JNKK, JNKK1, MAPKK4, MEK4, MKK4, PRKMK4, SAPKK-1, SAPKK1, SEK1, SERK1
Protein Interaction Partner: UBC, EGFR, GEMIN5, MAP3K5, MAP3K1, GCH1, MAPK10, MAPK9, MAPK8, MAPK1, ARRB2, ARRB1, MAP3K7, RBBP8, JUN, MAP2K7, APP, MAP3K2, MAPK14, AKT1, LRRK2, MAP2K4, MAP2K6, MAP3K4, MAP3K3, PML, BLNK, ITCH, MAPK8IP3, ZAK, SPAG9, TRIB1, MAP3K14, CFLAR, MAPK12, EFNA4,
Protein Size: 399 -
基因ID
- 6416
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NCBI登录号
- NM_003010, NP_003001
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UniProt
- P45985
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途径
- MAPK Pathway, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling
抗原
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