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FBXW7 抗体 (AA 599-707)

This anti-FBXW7 antibody is a 小鼠 单克隆 antibody detecting FBXW7 in WB, ELISA 和 IHC (p). Suitable for 人. This Primary Antibody has been cited in 5+ publications.
产品编号 ABIN527479
发货至: 中国

Quick Overview for FBXW7 抗体 (AA 599-707) (ABIN527479)

抗原

See all FBXW7 抗体
FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

适用

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宿主

  • 57
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小鼠

克隆类型

  • 60
  • 8
单克隆

标记

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This FBXW7 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

克隆位点

3D1
  • 抗原表位

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    AA 599-707

    原理

    Mouse monoclonal antibody raised against a partial recombinant FBXW7.

    序列

    ADSTVKIWDI KTGQCLQTLQ GPNKHQSAVT CLQFNKNFVI TSSDDGTVKL WDLKTGEFIR NLVTLESGGS GGVVWRIRAS NTKLVCAVGS RNGTEETKLL VLDFDVDMK

    交叉反应

    产品特性

    Antibody Reactive Against Recombinant Protein.

    免疫原

    FBXW7 (NP_361014, 599 a.a. ~ 707 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

    亚型

    IgG2a
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 缓冲液

    In 1x PBS, pH 7.4

    注意事项

    Aliquot to avoid repeated freezing and thawing.

    储存条件

    -20 °C

    储存方法

    Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
  • Hua, Ding, Yang: "Dysfunction of microRNA-32 regulates ubiquitin ligase FBXW7 in multiple myeloma disease." in: OncoTargets and therapy, Vol. 9, pp. 6573-6579, (2016) (PubMed).

    Yumimoto, Akiyoshi, Ueo, Sagara, Onoyama, Ueo, Ohno, Mori, Mimori, Nakayama: "F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner." in: The Journal of clinical investigation, Vol. 125, Issue 2, pp. 621-35, (2015) (PubMed).

    Yokobori, Yokoyama, Mogi, Endoh, Altan, Kosaka, Yamaki, Yajima, Tomizawa, Azuma, Onozato, Miyazaki, Tanaka, Kuwano: "FBXW7 mediates chemotherapeutic sensitivity and prognosis in NSCLCs." in: Molecular cancer research : MCR, Vol. 12, Issue 1, pp. 32-7, (2014) (PubMed).

    Lin, Hao, Nagata, Xu, Shang, Meng, Sato, Okuno, Varela, Ding, Garg, Liu, Yang, Yin, Shi, Jiang, Gu, Gong, Zhang, Xu, Kalid, Shacham, Ogawa, Wang, Koeffler: "Genomic and molecular characterization of esophageal squamous cell carcinoma." in: Nature genetics, Vol. 46, Issue 5, pp. 467-73, (2014) (PubMed).

    Enchev, Scott, da Fonseca, Schreiber, Monda, Schulman, Peter, Morris: "Structural basis for a reciprocal regulation between SCF and CSN." in: Cell reports, Vol. 2, Issue 3, pp. 616-27, (2012) (PubMed).

  • 抗原

    FBXW7 (F-Box and WD Repeat Domain Containing 7 (FBXW7))

    别名

    FBXW7

    背景

    Full Gene Name: F-box and WD repeat domain containing 7
    Synonyms: AGO,CDC4,DKFZp686F23254,FBW6,FBW7,FBX30,FBXO30,FBXW6,FLJ16457,SEL-10,SEL10

    基因ID

    55294

    NCBI登录号

    NM_033632

    途径

    Notch Signaling, EGFR Signaling Pathway
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