RUNX2 抗体 (AA 161-482)
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Quick Overview for RUNX2 抗体 (AA 161-482) (ABIN5027509)
抗原
See all RUNX2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 161-482
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纯化方法
- Protein A Chromatography
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免疫原
- A partial length recombinant RUNX2 protein (amino acids 161-482) was used as the immunogen for this antibody.
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亚型
- IgG
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应用备注
- WB: 1-3 μg/mL
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS containing 0.05 % BSA, PH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))
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别名
- RUNX2
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背景
- Runt-related transcription factor 2 (Runx2) is also known as core-binding factor subunit alpha-1 (CBF-alpha-1). RunX2 is one of the three mammalian transcription factors sharing the highly conserved DNA-binding Runt domain that represents a key class of lineage-specific gene regulators and is associated with different micro-environments during the cell cycle. RUNX2 has a primary role in the differentiation of osteoblasts and hypertrophy of cartilage at the growth plate, cell migration and vascular invasion of bone and is also expressed in vascular endothelial cells and breast cancer cells. It is a heterodimer of an alpha and a beta subunit. RUNX2 plays a role in the disease metaphyseal dysplasia with maxillary hypoplasia with or without brachydactyly, and cleidocranial dysplasia. By alternative splicing, several isoforms exist.
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分子量
- 50 kDa
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基因ID
- 860
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UniProt
- Q13950
抗原
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