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PTH 抗体 (AA 1-236)

PTH 适用: 人 IHC, WB 宿主: 小鼠 Monoclonal ABM4D44 unconjugated
产品编号 ABIN5027427
发货至: 中国
  • 抗原 See all PTH 抗体
    PTH (Parathyroid Hormone (PTH))
    抗原表位
    • 30
    • 26
    • 19
    • 13
    • 11
    • 9
    • 9
    • 8
    • 6
    • 6
    • 6
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-236
    适用
    • 160
    • 9
    • 9
    • 6
    • 6
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    宿主
    • 100
    • 72
    • 13
    • 2
    小鼠
    克隆类型
    • 98
    • 87
    单克隆
    标记
    • 115
    • 20
    • 13
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PTH antibody is un-conjugated
    应用范围
    • 69
    • 65
    • 57
    • 47
    • 40
    • 26
    • 23
    • 16
    • 14
    • 9
    • 8
    • 7
    • 6
    • 5
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB)
    纯化方法
    Protein G Chromatography
    免疫原
    A partial length recombinant Parathyroid Hormone protein (amino acids 1-236) was used as the immunogen for this antibody
    克隆位点
    ABM4D44
    亚型
    IgG2b kappa
    Top Product
    Discover our top product PTH Primary Antibody
  • 应用备注
    WB: 2-4 μg/mL, IHC: 5 μg/mL
    限制
    仅限研究用
  • 浓度
    0.5 mg/mL
    缓冲液
    PBS containing 0.05 % BSA, PH 7.4
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
  • 抗原
    PTH (Parathyroid Hormone (PTH))
    别名
    Parathyroid Hormone (PTH 产品)
    别名
    PTH1 antibody, Pthp antibody, PTH-(1-84) antibody, Pth1 antibody, Pthr1 antibody, PTH antibody, parathyroid hormone antibody, parathyroid hormone S homeolog antibody, PTH antibody, Pth antibody, pth.S antibody
    物质类
    Hormone
    背景
    Parathyroid hormone (PTH) produced and secreted by parathyroid glands, maintains mineral homeostasis by regulating calcium and phosphate absorption/reabsorption. It modulates phosphate homeostasis by downregulating Dentin matrix acidic phosphoprotein 1(DMP1) expression via the cAMP/PKA pathway targeting genes/proteins mutually governed by PTH. PTH secretion is characterized by an ultradian rhythm with tonic and pulsatile components. The majority of PTH is secreted in tonic fashion. Changes in the ultradian PTH secretion are correlated with skeletal fragility in primary and secondary osteoporosis. Plasma concentrations of Zn ions levels were significantly correlated with PTH levels. PTH in serum is typical for patients with chronic kidney disease (CKD). The onset of CKD is associated with pathway changes of protein synthesis and metabolism, amino acid metabolism, energy metabolism, and steroid hormone metabolism. Parathyroid hormones are bone-forming agents that have different modes of action on the bone. Lack of PTH in the central nervous system causes Hypoparathyroidism (HPT).
    分子量
    59 kDa
    基因ID
    5745
    UniProt
    Q03431
    途径
    cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process
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