GBL 抗体 (AA 100-320)
Quick Overview for GBL 抗体 (AA 100-320) (ABIN5027338)
抗原
See all GBL 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 100-320
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纯化方法
- Protein A Chromatography
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免疫原
- A partial length recombinant LST8/GBL protein (amino acids 100-320) was used as the immunogen for this antibody.
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亚型
- IgG
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应用备注
- WB: 1-3 μg/mL.
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限制
- 仅限研究用
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浓度
- 0.5 mg/mL
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缓冲液
- PBS containing 0.05 % BSA, PH 7.4
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
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- GBL (G protein beta subunit-like (GBL))
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别名
- LST8/GBL
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背景
- MLST8 or GbL (G protein beta protein subunit-like) is a subunit of mTORC1 and mTORC2 which regulates cell growth and survival. Both mTORC1 and 2 are activated in response to growth factors or amino acids but mTORC2 is most likely insensitive towards nutrients. Within mTORC1, LST8 interacts directly with mTOR and helps to enhance its kinase activity. mTORC1 phosphorylates EIF4EBP1 and thereby releasing it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. LST8/GBL more or less ubiquitously expressed with highest levels in skeletal muscle, heart and kidney.
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分子量
- 38 kDa
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基因ID
- 64223
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UniProt
- Q9BVC4
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途径
- PI3K-Akt Signaling, RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Actin Filament Polymerization, Autophagy, CXCR4-mediated Signaling Events, BCR Signaling, Warburg Effect
抗原
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