Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (Middle Region) 抗体
-
- 抗原 See all Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) 抗体
- Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)
-
抗原表位
- Middle Region
-
适用
- 人, 小鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- 非结合性
-
应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
- 特异性
- This antibody detects NADE / BEX3.
- 交叉反应 （详细）
- Species reactivity (tested):Human, mouse
- 纯化方法
- Ion exchange chromatography
- 免疫原
- NADE antibody was raised against a peptide corresponding to 14 amino acids near the middle of human NADE.
- 亚型
- IgG
- Top Product
- Discover our top product NGFRAP1 Primary Antibody
-
anti-Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (Center) antibody
NGFRAP1 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (AA 1-111) antibodyNGFRAP1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (AA 1-101) antibodyNGFRAP1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (AA 1-110) antibodyNGFRAP1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4E5 unconjugated
anti-Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1) (AA 1-111) antibodyNGFRAP1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
ELISA. Western blot: 0.5 to 2 μg/mL. Despite its predicted molecular weight, NADE migrates at approx. 23 kDa in SDS-PAGE. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
-
- 缓冲液
- PBS containing 0.02 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
-
- 抗原
- Nerve Growth Factor Receptor (TNFRSF16) Associated Protein 1 (NGFRAP1)
- 别名
- NADE / BEX3 (NGFRAP1 产品)
- 别名
- BEX3 antibody, Bex antibody, DXS6984E antibody, HGR74 antibody, NADE antibody, NGFRAP1 antibody, LNGFR antibody, Tnfrsf16 antibody, p75 antibody, p75NGFR antibody, p75NTR antibody, AL033356 antibody, Bex3 antibody, DXWsu67e antibody, Gcap27 antibody, Nade antibody, WBP5 antibody, brain expressed X-linked 3 antibody, nerve growth factor receptor (TNFR superfamily, member 16) antibody, BEX3 antibody, Ngfr antibody, Bex3 antibody
- 背景
- The p75 neurotrophin receptor (p75NTR) is a member of the tumor necrosis receptor superfamily and can mediate cell death and cell survival in response to nerve growth factor (NGF) (1 for review). The p75NTR-associated cell death executor (NADE) mediates apoptosis by interacting with the cell death domain of p75NTR following the binding of NGF by p75NTR (2). Recent studies have shown that NADE also interacts with second mitochondria-derived activator of caspase (Smac). Co-expression of NADE and Smac promotes TRAIL-induced apoptosis and inhibits XIAP-mediated Smac ubiquitization. It has been suggested that it is this interaction between NADE and Smac that allows apoptosis to proceed (5). Finally, although initially discovered as an mRNA expressed in ovarian granulosa cells (3), NADE has been suggested to play a role in the neuronal death seen in epileptic brain damage (4).Synonyms: Brain-expressed X-linked protein 3, DXS6984E, NGFRAP1, p75NTR-associated cell death executor
- 基因ID
- 27018
- NCBI登录号
- NP_996798
- UniProt
- Q00994
- 途径
- Neurotrophin Signaling Pathway, Positive Regulation of Endopeptidase Activity
-
