Survivin 抗体 (C-Term)
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Quick Overview for Survivin 抗体 (C-Term) (ABIN500292)
抗原
See all Survivin (BIRC5) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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特异性
- This antibody detects IAP4 / BIRC5 at C-term.
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交叉反应 (详细)
- Species reactivity (tested):Mouse
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纯化方法
- Peptide affinity chromatography
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免疫原
- Survivin antibody was raised against a synthetic peptide corresponding to amino acids near the carboxy terminus of mouse Survivin.
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亚型
- IgG
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应用备注
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ELISA. Western blot: 1 to 2 μg/mL, an approximate 17 kDa band can be detected. Immunohistochemistry on paraffin sections.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
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缓冲液
- PBS containing 0.02 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))
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别名
- IAP4 / BIRC5
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背景
- Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. A novel IAP protein was recently identified and designated survivin, apoptosis inhibitor 4 (API4), and TIAP (1-3). Survivin/TIAP interacted with the processed form of caspase-3 and inhibited its proteolytic activity. Survivin/TIAP is predominantly expressed in tissues of embryos, transformed cell lines, and many human cancers and lymphomas (1,3).Synonyms: API4, Apoptosis inhibitor 4, Apoptosis inhibitor survivin, Baculoviral IAP repeat-containing protein 5, Survivin
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基因ID
- 11799
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UniProt
- O70201
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途径
- Apoptosis, Cell Division Cycle, Nuclear Hormone Receptor Binding
抗原
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