Survivin 抗体 (pThr117)
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- 抗原 See all Survivin (BIRC5) 抗体
- Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))
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抗原表位
- pThr117
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Survivin antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- Phospho-Survivin (Thr117) Antibody detects endogenous levels of Survivin only when phosphorylated at Threonine 117.
- 预测反应
- Pig,Bovine,Horse,Sheep,Dog
- 纯化方法
- The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
- 免疫原
- A synthesized peptide derived from human Survivin around the phosphorylation site of Thr117.
- 亚型
- IgG
- Top Product
- Discover our top product BIRC5 Primary Antibody
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anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (AA 85-142) antibody
BIRC5 适用: 人, 小鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (AA 1-100) antibodyBIRC5 适用: 人 WB, ELISA, IF, IP, RNAi 宿主: 小鼠 Monoclonal 5B10 unconjugated
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (AA 1-142) antibodyBIRC5 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (AA 1-142) antibodyBIRC5 适用: 人 WB, IHC, ICC, IP 宿主: 小鼠 Monoclonal 1# unconjugated
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) antibodyBIRC5 适用: 人 WB, ELISA, IHC, ICC, FACS 宿主: 小鼠 Monoclonal 1H5 unconjugated
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (C-Term) antibodyBIRC5 适用: 人 WB, IF, IHC (p), ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (AA 1-142) antibodyBIRC5 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (AA 1-142) antibodyBIRC5 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) (AA 1-142) antibodyBIRC5 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat-Containing 5 (BIRC5) antibodyBIRC5 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- Survivin (BIRC5) (Baculoviral IAP Repeat-Containing 5 (BIRC5))
- 别名
- BIRC5 (BIRC5 产品)
- 别名
- AP14 antibody, API4 antibody, EPR-1 antibody, AAC-11 antibody, Api4 antibody, TIAP antibody, survivin40 antibody, bir5a antibody, survivin antibody, BIR1 antibody, Su2 antibody, XBIR1 antibody, XSurvivin1 antibody, Xsvv1 antibody, api4 antibody, bir1-A antibody, epr-1 antibody, svv1 antibody, xSurvivin antibody, xsurv antibody, Su1 antibody, birc5.2 antibody, svv2 antibody, xSurvivin2 antibody, bir5b antibody, SIX antibody, birc5.2-a antibody, birc5.2-b antibody, baculoviral IAP repeat containing 5 antibody, baculoviral IAP repeat-containing 5 antibody, baculoviral IAP repeat containing 5a antibody, baculoviral IAP repeat-containing 5, gene 1 L homeolog antibody, baculoviral IAP repeat containing 5 L homeolog antibody, baculoviral IAP repeat containing 5b antibody, baculoviral IAP repeat containing 5 S homeolog antibody, BIRC5 antibody, Birc5 antibody, birc5a antibody, birc5.1.L antibody, birc5.2.L antibody, birc5b antibody, birc5.2.S antibody
- 背景
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Description: Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex, directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797).
Gene: BIRC5
- 分子量
- 16kDa
- 基因ID
- 332
- UniProt
- O15392
- 途径
- Apoptosis, Cell Division Cycle, Nuclear Hormone Receptor Binding
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