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BAK1 抗体 (N-Term)

This anti-BAK1 antibody is a 兔 多克隆 antibody detecting BAK1 in WB, IF 和 EIA. Suitable for 人 和 小鼠.
产品编号 ABIN499405
发货至: 中国

Quick Overview for BAK1 抗体 (N-Term) (ABIN499405)

抗原

See all BAK1 抗体
BAK1 (BCL2-Antagonist/killer 1 (BAK1))

适用

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人, 小鼠

宿主

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克隆类型

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多克隆

标记

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This BAK1 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
  • 抗原表位

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    N-Term

    特异性

    Bak antibody was raised against a peptide corresponding to 13 amino acids near the amino-terminus of human Bak.

    纯化方法

    Ion exchange chromatography

    免疫原

    Human Bak (N-Terminus) Peptide

    亚型

    IgG
  • 应用备注

    ELISA. Western Blot: Bak antibody can be used for detection of Bak at 1 to 2 μg/mL. Immunocytochemistry.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user.

    限制

    仅限研究用
  • 缓冲液

    PBS containing 0.02 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    Store the antibody undiluted at 2-8 °C.
  • 抗原

    BAK1 (BCL2-Antagonist/killer 1 (BAK1))

    别名

    Bcl-2-Like 7

    背景

    Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death (reviewed in 2 and 3). Bak, a pro-apoptotic Bcl-2 family member, is an oligomeric protein that localizes to the mitochondria (4,5). It is thought to share significant functional homology with Bax, another pro-apoptotic Bcl-2 family member, as disruption of bak or bax has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking bak and bax show decreased apoptotic capability (6,7).Synonyms: Apoptosis regulator BAK, BAK, BAK1, BCL2L7, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 7, Bcl2-L-7, CDN1, cell death inhibitor 1

    基因ID

    578

    UniProt

    Q16611

    途径

    Apoptosis, Steroid Hormone Mediated Signaling Pathway, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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