BAK1 抗体 (N-Term)
Our Local Distributor
北京 101111
Quick Overview for BAK1 抗体 (N-Term) (ABIN499405)
抗原
See all BAK1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- N-Term
-
特异性
- Bak antibody was raised against a peptide corresponding to 13 amino acids near the amino-terminus of human Bak.
-
纯化方法
- Ion exchange chromatography
-
免疫原
- Human Bak (N-Terminus) Peptide
-
亚型
- IgG
-
-
-
-
应用备注
-
ELISA. Western Blot: Bak antibody can be used for detection of Bak at 1 to 2 μg/mL. Immunocytochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. -
限制
- 仅限研究用
-
-
-
缓冲液
- PBS containing 0.02 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C
-
储存方法
- Store the antibody undiluted at 2-8 °C.
-
-
- BAK1 (BCL2-Antagonist/killer 1 (BAK1))
-
别名
- Bcl-2-Like 7
-
背景
- Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer (reviewed in 1). The Bcl-2 family of proteins is comprised of critical regulators of apoptosis that can be divided into two classes: those that inhibit apoptosis and those that promote cell death (reviewed in 2 and 3). Bak, a pro-apoptotic Bcl-2 family member, is an oligomeric protein that localizes to the mitochondria (4,5). It is thought to share significant functional homology with Bax, another pro-apoptotic Bcl-2 family member, as disruption of bak or bax has little effect on cell death, but mice lacking both genes display multiple developmental defects and cells lacking bak and bax show decreased apoptotic capability (6,7).Synonyms: Apoptosis regulator BAK, BAK, BAK1, BCL2L7, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 7, Bcl2-L-7, CDN1, cell death inhibitor 1
-
基因ID
- 578
-
UniProt
- Q16611
-
途径
- Apoptosis, Steroid Hormone Mediated Signaling Pathway, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
抗原
-