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ATM 抗体 (C-Term)

Name: ATM 抗体 (C-Term)
SKU: ABIN499359
Availability: OutOfStock

ATM 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated

Western blot analysis of ATM in Daudi whole cell lysate with this product atM antibody at (A) 1 and (B) 2 μg/ml. (ATM 抗体 (C-Term))

Immunohistochemistry of ATM in human lymph node tissue with this product atM antibody at 2. (ATM 抗体 (C-Term))

IHC (p)

2 images

产品编号 ABIN499359

发货至: 中国

Datasheet as PDF

抗原 See all ATM 抗体

ATM (Ataxia Telangiectasia Mutated (ATM))
抗原表位
30

16

15

13

8

7

7

7

6

6

5

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
适用
152

79

32

3

2

1

1
人
宿主
133

19

6

2
兔
Compatible Secondaries
克隆类型
128

32
多克隆
标记
76

9

7

7

7

7

7

6

6

5

4

3

3

3

3

3

3

1
This ATM antibody is un-conjugated
应用范围
69

46

39

33

28

24

21

20

18

11

8

8

4

3

2

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

特异性

This antibody reacts to ATM.

纯化方法

Affinity chromatography purified via peptide column

免疫原

ATM antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human ATM.

亚型

IgG

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anti-Ataxia Telangiectasia Mutated (ATM) (AA 1974-1988), (pSer1981) antibody
ATM 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, FM 宿主: 小鼠 Monoclonal 10H11-E12 unconjugated

anti-Ataxia Telangiectasia Mutated (ATM) (C-Term) antibody
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anti-Ataxia Telangiectasia Mutated (ATM) (AA 2681-2750) antibody
ATM 适用: 人, 小鼠 WB, ELISA, IHC (p), IF (p), IF (cc), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Ataxia Telangiectasia Mutated (ATM) (AA 2484-2748) antibody
ATM 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Ataxia Telangiectasia Mutated (ATM) antibody
ATM 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Monoclonal 4E11 unconjugated Recombinant Antibody

anti-Ataxia Telangiectasia Mutated (ATM) (AA 1974-1988), (pSer1981) antibody (HRP)
ATM 适用: 人 WB, IHC, ELISA, FM 宿主: 小鼠 Monoclonal 10H11-E12 HRP

anti-Ataxia Telangiectasia Mutated (ATM) (AA 486-742) antibody
ATM 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Ataxia Telangiectasia Mutated (ATM) antibody
ATM 适用: 人 IHC, ELISA, FACS 宿主: 兔 Monoclonal 3G11 unconjugated Recombinant Antibody

anti-Ataxia Telangiectasia Mutated (ATM) antibody
ATM 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5C5 unconjugated

应用备注

ELISA. Western Blot: ATM antibody can be used for detection of ATM at 1 - 2 μg/mL. Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
缓冲液

PBS containing 0.02 % sodium azide.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C

储存方法

Store the antibody undiluted at 2-8 °C.
抗原

ATM (Ataxia Telangiectasia Mutated (ATM))

别名

ATM (ATM 产品)

别名

ATM antibody, Atm antibody, CG6535 antibody, Dmel\\CG6535 antibody, Tefu antibody, atm antibody, atm/tefu antibody, dATM antibody, tef antibody, Xatm antibody, at1 antibody, atdc antibody, tel1 antibody, telo1 antibody, AT1 antibody, ATA antibody, ATC antibody, ATD antibody, ATDC antibody, ATE antibody, TEL1 antibody, TELO1 antibody, AI256621 antibody, C030026E19Rik antibody, telomere fusion antibody, ATM serine/threonine kinase L homeolog antibody, ATM serine/threonine kinase antibody, ataxia telangiectasia mutated antibody, ataxia telangiectasia mutated (atm) antibody, serine/threonine-protein kinase ATM antibody, tefu antibody, atm.L antibody, atm antibody, ATM antibody, EDI_100660 antibody, CpipJ_CPIJ001772 antibody, BDBG_08252 antibody, PAAG_02532 antibody, MCYG_05088 antibody, VDBG_06833 antibody, ACLA_015700 antibody, LOC5565620 antibody, MGYG_07634 antibody, PGTG_14279 antibody, Atm antibody

背景

DNA double strand breaks represent a major threat to an organism's genome. Eukaryotic cells have developed mechanisms that sense the presence this damage and initiate suitable responses that can include DNA repair, cell cycle delay, and programmed cell death. The ATM (mutated in Ataxia-Telangiectasia) protein kinase is activated following the formation of DNA double strand breaks, phosphorylating p53 and another kinase CHK2. This initiates a signaling cascade leading to the phosphorylation and inhibition of Cdc25, ultimately preventing cell cycle progression. In some cell types, such as the hemapoietic system, this leads to apoptosis instead of cell cycle arrest. Multiple isoforms of ATM are known to exist.Synonyms: A-T mutated, ATDC, Ataxia telangiectasia mutated, Serine-protein kinase ATM, TEL1, TELO1

基因ID

472

UniProt

Q13315

途径

p53 Pathway, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus