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- 抗原 See all RYR2 抗体
- RYR2 (Ryanodine Receptor 2 (Cardiac) (RYR2))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RYR2 antibody is un-conjugated
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应用范围
- Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- This antibody detects endogenous levels of RyR2 protein.
- 交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - 纯化方法
- Affinity Chromatography using epitope-specific immunogen.
- Top Product
- Discover our top product RYR2 Primary Antibody
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anti-Ryanodine Receptor 2 (Cardiac) (RYR2) (AA 901-1192) antibody
RYR2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Ryanodine Receptor 2 (Cardiac) (RYR2) (AA 4850-4950) antibodyRYR2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Ryanodine Receptor 2 (Cardiac) (RYR2) (pSer2808) antibodyRYR2 适用: 人, 小鼠, 大鼠, 兔 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Ryanodine Receptor 2 (Cardiac) (RYR2) (AA 1489-1502), (Intracellular), (N-Term) antibodyRYR2 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Ryanodine Receptor 2 (Cardiac) (RYR2) antibodyRYR2 适用: 人, 小鼠, 大鼠 ELISA, WB, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ryanodine Receptor 2 (Cardiac) (RYR2) (Tyr1018) antibodyRYR2 适用: 人, 小鼠, 大鼠 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Immunhistochemistry on paraffin sections: 1: 50 - 1: 200. Immunoflourescence: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS), pH ~7.2 containing 0.05 % Sodium Azide as preservative.
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- 抗原
- RYR2 (Ryanodine Receptor 2 (Cardiac) (RYR2))
- 别名
- Ryanodine Receptor 2 / RYR2 (RYR2 产品)
- 别名
- RYR2 antibody, ARVC2 antibody, ARVD2 antibody, RYR-2 antibody, RyR antibody, VTSIP antibody, 9330127I20Rik antibody, ryanodine receptor 2 antibody, ryanodine receptor 2, cardiac antibody, RYR2 antibody, Ryr2 antibody
- 背景
- Dihydropyridine receptor (DHPR) is a surface membrane protein critical for the excitation-contraction coupling of striated muscle. DHPR and the sarcoplasmic reticulum ryanodine receptor (RyR) are two key components of the intracellular junctions, where depolarization of the surface membrane is converted into the release of Ca2+ from internal stores. The α1-subunit of the DHPR contains a cytoplasmic loop which is thought to be involved in the interactions with RyR. Phosphorylation of the DHPR α1-subunit is also thought to play a role in the functional interaction of DHPR and RyR. Mutation in DHPR α1 results in excitation-contraction uncoupling, leading to muscular dysgenesis, a complete inactivity in developing skeletal muscles. Cells that do not express RyR also lack excitation-contraction coupling and exhibit a severalfold reduction in Ca2+ current density.Synonyms: Cardiac muscle ryanodine receptor, Cardiac muscle ryanodine receptor-calcium release channel, Type 2 ryanodine receptor
- 分子量
- approx. 565 kDa
- 基因ID
- 6262
- NCBI登录号
- NP_001026
- UniProt
- Q92736
- 途径
- Myometrial Relaxation and Contraction
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