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- 抗原 See all GRIA4 抗体
- GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GRIA4 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- This antibody detects endogenous levels of GluR4 protein.
- 交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. - 纯化方法
- Affinity chromatography using epitope-specific immunogen
- 纯度
- > 95 % (by SDS-PAGE)
- Top Product
- Discover our top product GRIA4 Primary Antibody
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anti-Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4) antibody
GRIA4 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4) (Internal Region) antibodyVerified GRIA4 适用: 人 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4) (AA 296-325) antibodyGRIA4 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB30232 unconjugated
anti-Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4) (AA 351-450) antibodyGRIA4 适用: 小鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4) (AA 733-883) antibodyGRIA4 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4) (AA 295-325), (Middle Region) antibodyGRIA4 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4) antibodyGRIA4 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4) antibodyGRIA4 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4) (Ser433) antibodyGRIA4 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4) antibodyGRIA4 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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- 应用备注
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Western blot: 1: 500 - 1: 1000. Immunohistochemistry on paraffin sections: 1: 50 - 1: 200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.
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- 抗原
- GRIA4 (Glutamate Receptor, Ionotropic, AMPA 4 (GRIA4))
- 别名
- Glutamate Receptor 4 / GLUR4 (GRIA4 产品)
- 别名
- GLUR4 antibody, GLUR4C antibody, GLURD antibody, GluA4 antibody, GluR4 antibody, GluR4d antibody, GLUR4/D antibody, glur4 antibody, GluR-D antibody, Glur-4 antibody, Glur4 antibody, Gluralpha4 antibody, spkw1 antibody, DKFZp459P0616 antibody, glur4a antibody, gria4 antibody, iGluR4 antibody, ZfGluR4b antibody, fj46g06 antibody, glur4b antibody, wu:fj46g06 antibody, glutamate ionotropic receptor AMPA type subunit 4 antibody, glutamate receptor, ionotropic, AMPA 4 antibody, glutamate receptor, ionotropic, AMPA4 (alpha 4) antibody, glutamate receptor, ionotropic, AMPA 4a antibody, glutamate receptor, ionotropic, AMPA 4b antibody, GRIA4 antibody, gria4 antibody, Gria4 antibody, gria4a antibody, gria4b antibody
- 背景
- G protein-coupled inwardly rectifying potassium channels (KIR3.1 through KIR3.4) are coupled to numerous neurotransmitter receptors in the brain and are abundantly expressed in the olfactory bulb, hippocampus, neocortex, dentate gyrus, cerebellar cortex and thalamus regions of the brain. Also known as GIRK, KIR3 potassium channels localize to the soma and dendrites as well as axons of neurons. Liberated Gbγ subunits from G protein heterotrimers bind to and regulate KIR3 channel activity. Gb3- and Gb4-containing Gbγ dimers bind directly to cytoplasmic domains of KIR3 proteins and increase the K+ current while Gb5-containing Gbγ dimers inhibit KIR3 K+ current. KIR3 activity is also inhibited by tyrosine phosphorylation. Brain-derived neurotrophic factor activates receptor tyrosine kinase B, which then phosphorylates KIR3 tyrosine residues, effectively inactivating the KIR3 channels.Synonyms: AMPA-selective glutamate receptor 4, GRIA4, GluA4, GluR-4, GluR-D, Glutamate receptor ionotropic AMPA4
- 分子量
- approx. 100 kDa
- 基因ID
- 2893
- NCBI登录号
- NP_000820
- UniProt
- P48058
- 途径
- PI3K-Akt Signaling
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