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Lamin A/C 抗体 (AA 59-249)

Name: Lamin A/C 抗体 (AA 59-249)
SKU: ABIN497933
Availability: OutOfStock

LMNA 适用: 人, 小鼠, 大鼠, Cow WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

Western Blot: Lamin A/C antibody staining of HeLa Nucleus (A) (20 µg) at 1/3000 dilution, 10% SDS PAGE. (Lamin A/C 抗体 (AA 59-249))

Immunohistochemistry: Lamin A/C antinbody staining of Paraffin-Embedded H441 Xenograft at 1/100 dilution. (Lamin A/C 抗体 (AA 59-249))

IHC (p)

2 images

产品编号 ABIN497933

发货至: 中国

Datasheet as PDF

抗原 See all Lamin A/C (LMNA) 抗体

Lamin A/C (LMNA)
抗原表位
10

8

8

8

7

7

6

6

5

4

4

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 59-249
适用
141

81

76

25

15

13

8

7

6

6

6

4

4

3

3

2

2

1

1

1

1

1

1
人, 小鼠, 大鼠, Cow
宿主
107

42

3

1
兔
Compatible Secondaries
克隆类型
107

46
多克隆
标记
110

10

9

8

3

3

2

2

1

1

1

1

1

1
This Lamin A/C antibody is un-conjugated
应用范围
122

55

52

47

31

28

27

19

13

7

3

2

2

1

1
Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

特异性

Recognizes Lamin A/C.

交叉反应（详细）

Species reactivity (expected):Mouse (98 %), Rat (98 %), Bovine (98 %).
Species reactivity (tested):Human.

纯化方法

Antigen-Affinity Chromatography.

免疫原

Recombinant protein fragment contain a sequence corresponding to a region within amino acids 59 and 249 of Lamin A/C

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应用备注

Western blotting: 1/500-1/3000. Positive Controls: HeLa, HeLa NucleusImmunohistochemistry on Paraffin Sections: 1/100-1/500.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

限制

仅限研究用
状态

Liquid

浓度

1.0 mg/mL

缓冲液

0.1 M Tris, 0.1 M Glycine, 10 % Glycerol and 0.01 % Thimerosal as preservative.

储存液

Thimerosal (Merthiolate)

注意事项

This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

Avoid repeated freezing and thawing.

储存条件

-20 °C

储存方法

Store the antibody undiluted (in aliquots) at -20 °C.
抗原

Lamin A/C (LMNA)

别名

Lamin-A/C (LMNA) (LMNA 产品)

别名

CDCD1 antibody, CDDC antibody, CMD1A antibody, CMT2B1 antibody, EMD2 antibody, FPL antibody, FPLD antibody, FPLD2 antibody, HGPS antibody, IDC antibody, LDP1 antibody, LFP antibody, LGMD1B antibody, LMN1 antibody, LMNC antibody, LMNL1 antibody, PRO1 antibody, Dhe antibody, 2459 antibody, 74/76 antibody, CG6944 antibody, D5 antibody, DM[[O]] antibody, Dm antibody, Dm(0) antibody, Dm0 antibody, Dm1 antibody, Dm2 antibody, DmLamin antibody, DmO antibody, Dm[[0]] antibody, Dm[[1]] antibody, Dm[[2]] antibody, Dm[[mit]] antibody, Dm[[o]] antibody, Dmel\\CG6944 antibody, Dmo antibody, LAM antibody, Lam Dm[[0]] antibody, Lam(Dm0) antibody, LamDm[[0]] antibody, LamDm[[o]] antibody, Lam[[Dm0]] antibody, Lamin Dm[[0]] antibody, jf27 antibody, l(2)04643 antibody, l(2)25Ec antibody, l(2)gdh-7 antibody, l(2)gdh7 antibody, l(2)jf27 antibody, lam antibody, lamDm0 antibody, lamDm[[0]] antibody, lamin antibody, lamin Dm0 antibody, lamin Dm[[0]] antibody, misg antibody, nlam antibody, cb948 antibody, fk66d12 antibody, wu:fk66d12 antibody, lmna-A antibody, fpl antibody, idc antibody, lfp antibody, cddc antibody, emd2 antibody, fpld antibody, hgps antibody, ldp1 antibody, lmn1 antibody, lmnc antibody, pro1 antibody, cdcd1 antibody, cmd1a antibody, cmt2b1 antibody, lgmd1b antibody, Lamin-A antibody, lamin-L(III)-like antibody, lamin A/C antibody, lamin A antibody, Lamin antibody, lamin A/C L homeolog antibody, lamin-L(III)-like antibody, LMNA antibody, Lmna antibody, Lam antibody, lmna antibody, lmna.L antibody, LMINA antibody

背景

Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A type lamins and B type lamins. The A type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. Lamin A, Lamin C and lamin Adel 10, while the B type lamins include two proteins arising from two distinct genes, i.e. Lamin B1 and Lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A type lamins coincides with cell differentiation and as A type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A type lamins.Synonyms: 70 kDa Lamin, LMN1, LMNA, Lamin A, Lamin A + C, Lamin-A/C, NY-REN-32, NYREN32, Nuclear Envelope Marker, Renal carcinoma antigen NY-REN-32

基因ID

4000, 9606

UniProt

P02545

途径

Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus