TRAF6 抗体 (AA 314-343)
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Quick Overview for TRAF6 抗体 (AA 314-343) (ABIN3029155)
抗原
See all TRAF6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 314-343
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交叉反应 (详细)
- Expected species reactivity: Mouse, Bovine
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 314-343 from the human protein was used as the immunogen for this TRAF6 antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the TRAF6 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the TRAF6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- TRAF6 (TNF Receptor-Associated Factor 6 (TRAF6))
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别名
- TRAF6
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背景
- The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein mediates the signaling not only from the members of the TNF receptor superfamily, but also from the members of the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. Two alternatively spliced transcript variants encoding identical proteins have been reported. [provided by RefSeq].
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UniProt
- Q9Y4K3
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途径
- NF-kappaB Signaling, TCR Signaling, TLR signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Hepatitis C, Toll-Like Receptors Cascades, Ubiquitin Proteasome Pathway
抗原
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