Tuberin 抗体 (pSer1420)
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Quick Overview for Tuberin 抗体 (pSer1420) (ABIN3029326)
抗原
See all Tuberin (TSC2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer1420
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纯化方法
- Antigen affinity purified
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免疫原
- This phospho-TSC2 antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS1420 of human TSC2.
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亚型
- Ig Fraction
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应用备注
- Titration of the phospho-TSC2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500,Immunofluorescence: 1:10-1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the phospho-TSC2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- Tuberin (TSC2) (Tuberous Sclerosis 2 (TSC2))
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别名
- TSC2
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背景
- Mutations in TSC2 lead to tuberous sclerosis complex. The protein is believed to be a tumor suppressor and is able to specifically stimulate the intrinsic GTPase activity of the Ras-related protein RAP1A and RAB5. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. TSC2 may have a function in vesicular transport, but may also play a role in the regulation of cell growth arrest and in the regulation of transcription mediated by steroid receptors. Interaction between TSC1 and TSC2 may facilitate vesicular docking.
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UniProt
- P49815
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途径
- RTK signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus
抗原
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