FAS 抗体 (pTyr291)
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北京 101111
Quick Overview for FAS 抗体 (pTyr291) (ABIN3030905)
抗原
See all FAS 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pTyr291
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纯化方法
- Antigen affinity purified
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免疫原
- This phospho-FAS antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pY291 of human FAS.
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亚型
- Ig Fraction
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应用备注
- Titration of the phospho-FAS antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS pH 7.4 with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the phospho-FAS antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- FAS (TNF Receptor Superfamily, Member 6 (FAS))
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别名
- Fas
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背景
- Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). [UniProt]
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UniProt
- P25445
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途径
- p53 Pathway, Apoptosis, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity
抗原
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