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ATM 抗体 (pSer1981)

This anti-ATM antibody (ABIN3030033) is a Rabbit Polyclonal antibody detecting ATM in ELISA, IF, DB. Suitable for Human.
产品编号 ABIN3030033
发货至: 中国

Quick Overview for ATM 抗体 (pSer1981) (ABIN3030033)

抗原

See all ATM 抗体
ATM (Ataxia Telangiectasia Mutated (ATM))

适用

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宿主

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克隆类型

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多克隆

标记

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This ATM antibody is un-conjugated

应用范围

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ELISA, Immunofluorescence (IF), Dot Blot (DB)
  • 抗原表位

    • 32
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    pSer1981

    纯化方法

    Antigen affinity purified

    免疫原

    This phospho-ATM antibody was produced from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding pS1981 of human ATM.

    亚型

    Ig Fraction
  • 应用备注

    Titration of the phospho-ATM antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Dot blot: 1:500,Immunofluorescence: 1:10-1:50

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    In 1X PBS, pH 7.4, with 0.09 % sodium azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Aliquot the phospho-ATM antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
  • 抗原

    ATM (Ataxia Telangiectasia Mutated (ATM))

    别名

    ATM

    背景

    ATM belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates, thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2,checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. ATM and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in the gene encoding ATM are associated with ataxia telangiectasia, an autosomal recessive disorder.

    UniProt

    Q13315

    途径

    p53 Pathway, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus
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