GTPase NRas 抗体 (AA 147-179)
Quick Overview for GTPase NRas 抗体 (AA 147-179) (ABIN3031131)
抗原
See all GTPase NRas (NRAS) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 147-179
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交叉反应 (详细)
- Expected species reactivity: Pig
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纯化方法
- Purified
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免疫原
- A portion of amino acids 147-179 from the human protein was used as the immunogen for this NRAS antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the NRAS antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:50,Flow Cytometry: 1:10-1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the NRAS antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- GTPase NRas (NRAS)
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别名
- NRAS
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背景
- NRAS is a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. This protein, which has intrinsic GTPase activity, is activated to a GTP-bound form by a GTPase activating protein and inactivated to a GDP-bound form by a guanine nucleotide-exchange factor. Defects in the gene encoding this protein are a cause of juvenile myelomonocytic leukemia (JMML).
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UniProt
- P01111
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途径
- p53 Pathway, MAPK Pathway, RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Hepatitis C, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling
抗原
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