LKB1 抗体 (AA 19-48)
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北京 101111
Quick Overview for LKB1 抗体 (AA 19-48) (ABIN3032541)
抗原
See all LKB1 (STK11) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 19-48
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交叉反应 （详细）
- Expected species reactivity: Mouse, Rat, Chicken
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纯化方法
- Purified
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免疫原
- A portion of amino acids 19-48 from the human protein was used as the immunogen for this LKB1 antibody.
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亚型
- Ig Fraction
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anti-serine/threonine Kinase 11 (STK11) (AA 134-433) antibody
STK11 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (AA 14-44), (N-Term) antibodySTK11 适用: 人 WB, IF, IHC (p), FACS 宿主: 兔 Polyclonal RB3547 unconjugated
anti-serine/threonine Kinase 11 (STK11) (AA 14-44) antibodySTK11 适用: 人 WB, ELISA, IHC, IF, FACS 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (pSer428) antibodySTK11 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (pThr189) antibodySTK11 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (Internal Region) antibodySTK11 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (AA 1-433) antibodySTK11 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) (N-Term) antibodySTK11 适用: 人, 小鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 11 (STK11) antibodySTK11 适用: 人, 小鼠, 猴 WB, ELISA, FACS 宿主: 小鼠 Monoclonal 4H12 unconjugated
anti-serine/threonine Kinase 11 (STK11) (AA 393-420), (C-Term) antibodySTK11 适用: 小鼠 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB37144 unconjugated
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应用备注
- Titration of the LKB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50,Immunofluorescence: 1:10-1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the LKB1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- LKB1 (STK11) (serine/threonine Kinase 11 (STK11))
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别名
- LKB1
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背景
- LKB1 is a tumor suppressor serine/threonine-protein kinase that controls the activity of AMP-activated protein kinase (AMPK) family members, thereby playing a role in various processes such as cell metabolism, cell polarity, apoptosis and DNA damage response. Acts as a key upstream regulator of AMPK by mediating phosphorylation and activation of AMPK catalytic subunits PRKAA1 and PRKAA2 and thereby regulates processes including: inhibition of signaling pathways that promote cell growth and proliferation when energy levels are low, glucose homeostasis in liver, activation of autophagy when cells undergo nutrient deprivation, and B-cell differentiation in the germinal center in response to DNA damage. [UniProt]
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UniProt
- Q15831
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途径
- AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect
抗原
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