IRAK1 抗体 (AA 405-433)
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Quick Overview for IRAK1 抗体 (AA 405-433) (ABIN3028764)
抗原
See all IRAK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 405-433
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 405-433 from the mouse protein was used as the immunogen for this Irak1 antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the Irak1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,Flow Cytometry: 1:10-1:50
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the Irak1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))
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别名
- Irak1
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背景
- Irak1 binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. The kinase activity of this enzyme may not be required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1.
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UniProt
- Q62406
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途径
- NF-kappaB Signaling, TLR signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
抗原
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