IRAK1 抗体 (AA 683-712)
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北京 101111
Quick Overview for IRAK1 抗体 (AA 683-712) (ABIN3031490)
抗原
See all IRAK1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 683-712
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纯化方法
- Purified
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免疫原
- A portion of amino acids 683-712 from the human protein was used as the immunogen for this IRAK antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the IRAK antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000,IHC (Paraffin): 1:10-1:100
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the IRAK antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- IRAK1 (Interleukin-1 Receptor-Associated Kinase 1 (IRAK1))
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别名
- IRAK
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背景
- Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine-like kinase (TLK) group consists of 40 tyrosine and serine-threonine kinases such as MLK (mixed-lineage kinase), LISK (LIMK/TESK), IRAK (interleukin-1 receptor-associated kinase), Raf, RIPK (receptor-interacting protein kinase), and STRK (activin and TGF-beta receptors) families.
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UniProt
- P51617
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途径
- NF-kappaB Signaling, TLR signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades
抗原
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