HGF 抗体 (AA 521-554)
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Quick Overview for HGF 抗体 (AA 521-554) (ABIN3031185)
抗原
See all HGF 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 521-554
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纯化方法
- Purified
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免疫原
- A portion of amino acids 521-554 from the human protein was used as the immunogen for this HGF antibody.
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亚型
- IgG1
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应用备注
- Titration of the HGF antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:100-1:250
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the HGF antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- HGF (Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF))
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别名
- HGF
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背景
- Hepatocyte Growth Factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 64- kDa alpha-chain and 34- kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms. [provided by RefSeq].
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UniProt
- P14210
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途径
- RTK signaling, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor
抗原
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