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HGF 抗体 (N-Term)

There are 5+ publications for this product available. The 兔 多克隆 anti-HGF antibody is suitable to detect HGF in samples from 人, 大鼠, 小鼠, 犬, 绵羊, 兔, Cow, 马, 豚鼠, Pig 和 斑马鱼. It has been validated for WB 和 IHC.
Pubmed (5 references)
产品编号 ABIN2781816
发货至: 中国
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for HGF 抗体 (N-Term) (ABIN2781816)

抗原

See all HGF 抗体
HGF (Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF))

适用

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人, 大鼠, 小鼠, 犬, 绵羊, 兔, Cow, 马, 豚鼠, Pig, 斑马鱼

宿主

  • 75
  • 40
  • 6
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兔

克隆类型

  • 82
  • 45
多克隆

标记

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This HGF antibody is un-conjugated

应用范围

  • 90
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Western Blotting (WB), Immunohistochemistry (IHC)
Discover our top product HGF Primary Antibody

  • 抗原表位

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    N-Term

    序列

    VKKEFGHEFD LYENKDYIRN CIIGKGRSYK GTVSITKSGI KCQPWSSMIP

    特异性

    100 % homologous to all 6 isoforms, 1 (83 kDa), 2 (34 kDa), 3 (83 kDa), 4 (35 kDa), 5 (33 kDa), 6 (24 kDa)

    预测反应

    Cow: 100%, Dog: 100%, Guinea Pig: 93%, Horse: 100%, Human: 100%, Mouse: 100%, Pig: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 80%

    产品特性

    This is a rabbit polyclonal antibody against HGF. It was validated on Western Blot using a cell lysate as a positive control.

    纯化方法

    Affinity Purified

    免疫原

    The immunogen is a synthetic peptide directed towards the N terminal region of human HGF
  • anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 1-728) antibody
    anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 1-728) antibody

    HGF 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

    anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 521-554) antibody
    anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 521-554) antibody

    HGF 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated

    anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 201-300) antibody
    anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 201-300) antibody

    HGF 适用: 人, 大鼠, 小鼠, 绵羊 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

    anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 482-710) antibody
    anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 482-710) antibody

    HGF 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

    anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 306-471) antibody
    anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 306-471) antibody

    HGF 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

    anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 216-265) antibody
    anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 216-265) antibody

    HGF 适用: 人, 大鼠, 小鼠, 犬, 兔, Cow, 马, 豚鼠, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

    anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 521-554), (C-Term) antibody
    anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 521-554), (C-Term) antibody

    HGF 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB09924 unconjugated

    anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 495-728) antibody
    anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 495-728) antibody

    HGF 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C1 unconjugated

    anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 619-728) antibody
    anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 619-728) antibody

    HGF 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

    anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 33-64), (N-Term) antibody
    anti-Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF) (AA 33-64), (N-Term) antibody

    HGF 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated

  • 应用备注

    Optimal working dilutions should be determined experimentally by the investigator.

    说明

    Antigen size: 728 AA

    限制

    仅限研究用

  • 状态

    Liquid

    浓度

    Lot specific

    缓冲液

    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and may contain up to 2 % sucrose.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze-thaw cycles.

    储存条件

    -20 °C

    储存方法

    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Nejak-Bowen, Orr, Bowen, Michalopoulos: "Conditional genetic elimination of hepatocyte growth factor in mice compromises liver regeneration after partial hepatectomy." in: PLoS ONE, Vol. 8, Issue 3, pp. e59836, (2013) (PubMed).

    Ji, Zhang, You, Li, Liu, Jiang, Liu, Zhang, Wang, Tao, Dou: "The differentiation of MSCs into functional hepatocyte-like cells in a liver biomatrix scaffold and their transplantation into liver-fibrotic mice." in: Biomaterials, Vol. 33, Issue 35, pp. 8995-9008, (2012) (PubMed).

    Zampell, Avraham, Yoder, Fort, Yan, Weitman, Mehrara: "Lymphatic function is regulated by a coordinated expression of lymphangiogenic and anti-lymphangiogenic cytokines." in: American journal of physiology. Cell physiology, Vol. 302, Issue 2, pp. C392-404, (2012) (PubMed).

    Sen, Peng, Saigal, Williams, Johnson: "Distinct interactions between c-Src and c-Met in mediating resistance to c-Src inhibition in head and neck cancer." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 3, pp. 514-24, (2011) (PubMed).

    Williams, Mehta, Peyton, Zeiger, Van Vliet, Griffith: "Autocrine-controlled formation and function of tissue-like aggregates by primary hepatocytes in micropatterned hydrogel arrays." in: Tissue engineering. Part A, Vol. 17, Issue 7-8, pp. 1055-68, (2011) (PubMed).

  • 抗原

    HGF (Hepatocyte Growth Factor (Hepapoietin A, Scatter Factor) (HGF))

    别名

    HGF

    背景

    Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69- kDa alpha-chain and 34- kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity.Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69- kDa alpha-chain and 34- kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
    Alias Symbols: F-TCF, HGFB, HPTA, SF, DFNB39
    Protein Interaction Partner: ADAMTSL4, MEOX2, MET, F11, ST14, HGFAC, LCN2, KLKB1, VTN, PLAU, CLEC3B, SDC1, SDC2, HPN, HGF, FN1, NRP1,
    Protein Size: 728

    分子量

    83 kDa

    基因ID

    3082

    NCBI登录号

    NM_001010932, NP_001010932

    UniProt

    P14210

    途径

    RTK signaling, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor
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