HES1 抗体 (C-Term)
Quick Overview for HES1 抗体 (C-Term) (ABIN3031193)
抗原
See all HES1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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交叉反应 (详细)
- Expected species reactivity: Bovine
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纯化方法
- Antigen affinity purified
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免疫原
- This HES1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 259-293 amino acids from the C-terminal region of human HES1.
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亚型
- Ig Fraction
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应用备注
- Titration of the HES1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the HES1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- HES1 (Hes Family bHLH Transcription Factor 1 (HES1))
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别名
- HES1
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背景
- Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.
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UniProt
- Q14469
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途径
- DNA Damage Repair
抗原
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