我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

HES1 抗体 (N-Term)

There are 13+ publications for this product available. The 兔多克隆 anti-HES1 antibody is suitable to detect HES1 in samples from 人, 小鼠, 大鼠, Cow, 兔, 豚鼠, 斑马鱼和马. It has been validated for WB, IHC, IF 和 IP.

WB Suggested Anti-HES1 Antibody Titration: 1. (HES1 抗体 (N-Term))

HES1 antibody - N-terminal region validated by WB using transfected Ls174Tcell lysate at 1ug/ml. (HES1 抗体 (N-Term))

HES1 antibody - N-terminal region validated by WB using Mouse embryo tissue at 1:800. (HES1 抗体 (N-Term))

transfected Ls174T cell lysate at 50ug/ml. (HES1 抗体 (N-Term))

Rabbit Anti-HES1 Antibody Paraffin Embedded Tissue: Human cardiac cell Cellular Data: Epithelial cells of renal tubule Antibody Concentration: 4. (HES1 抗体 (N-Term))

IHC

8 images

(13 references)

产品编号 ABIN2779597

发货至: 中国

Contact our Customer Service for availability and price in your country. Contact Info

Our Local Distributor

中国
北京 101111

No. 88 KeChuang 6th Street

Beijing Economic Technological Development Area

Room 801-803

4A Biotech Co.,Ltd.

Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for HES1 抗体 (N-Term) (ABIN2779597)

抗原

See all HES1 抗体

HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

适用

人, 小鼠, 大鼠, Cow, 兔, 豚鼠, 斑马鱼, 马

宿主

兔

克隆类型

多克隆

标记

This HES1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

抗原表位
16

9

8

5

3

3

2

2

2

2

1

1

1

1

1

1

1

1

1

1
N-Term

原理

HES1 Antibody - N-terminal region

序列

NTTPDKPKTA SEHRKSSKPI MEKRRRARIN ESLSQLKTLI LDALKKDSSR

预测反应

Cow: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Zebrafish: 100%

产品特性

This is a rabbit polyclonal antibody against HES1. It was validated on Western Blot and immunohistochemistry.

纯化方法

Protein A purified

免疫原

The immunogen is a synthetic peptide directed towards the N terminal region of human HES1
anti-Hes Family bHLH Transcription Factor 1 (HES1) (AA 41-150) antibody
HES1 适用: 人 WB, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Hes Family bHLH Transcription Factor 1 (HES1) antibody
HES1 适用: 人 WB, IHC, IP 宿主: 兔 Monoclonal unconjugated

anti-Hes Family bHLH Transcription Factor 1 (HES1) (AA 9-38), (N-Term) antibody
HES1 适用: 人 WB, IF, FACS 宿主: 兔 Polyclonal RB13980 unconjugated

anti-Hes Family bHLH Transcription Factor 1 (HES1) (AA 24-35) antibody
HES1 适用: 人, 小鼠, 大鼠, Cow, 兔, 斑马鱼, 马, 猴, Bat, 非洲爪蟾, Hamster WB, IHC, IF, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Hes Family bHLH Transcription Factor 1 (HES1) (AA 1-277) antibody
HES1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Hes Family bHLH Transcription Factor 1 (HES1) (AA 9-38) antibody
HES1 适用: 人 WB, ELISA, IF, FACS 宿主: 兔 Polyclonal unconjugated

anti-Hes Family bHLH Transcription Factor 1 (HES1) (AA 151-280) antibody
HES1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-Hes Family bHLH Transcription Factor 1 (HES1) antibody
Microarray verified HES1 适用: 人, 小鼠 IHC 宿主: 小鼠 Monoclonal MAB869233 unconjugated

anti-Hes Family bHLH Transcription Factor 1 (HES1) antibody
HES1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 7B9 unconjugated

anti-Hes Family bHLH Transcription Factor 1 (HES1) (N-Term) antibody
HES1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

说明

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under ABIN8102415

限制

仅限研究用
状态

Liquid

浓度

1.0 mg/mL

缓冲液

Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

注意事项

prevent freeze-thaw cycles

储存条件

4 °C,-20 °C

储存方法

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Zhang, Weimann, Stolzenburg, Neuhaus, Berndt-Paetz: "Notch2/3-DLL4 interaction in urothelial cancer cell lines supports a tumorigenic role of Notch signaling pathways in bladder carcinoma." in: PloS one, Vol. 20, Issue 2, pp. e0317709, (2025) (PubMed).

Sun, Zhou, Liu, Zhang, Chen, Pan, Ma, Liu, Du, Yang, Wang: "Inhibition of breast cancer cell survival by Xanthohumol via modulation of the Notch signaling pathway in vivo and in vitro." in: Oncology letters, Vol. 15, Issue 1, pp. 908-916, (2018) (PubMed).

Natsumeda, Maitani, Liu, Miyahara, Kaur, Chu, Zhang, Kahlert, Eberhart: "Targeting Notch Signaling and Autophagy Increases Cytotoxicity in Glioblastoma Neurospheres." in: Brain pathology (Zurich, Switzerland), Vol. 26, Issue 6, pp. 713-723, (2015) (PubMed).

Meng, Su, Liu, Wang, Wang: "Rac1 contributes to cerebral ischemia reperfusion-induced injury in mice by regulation of Notch2." in: Neuroscience, Vol. 306, pp. 100-14, (2015) (PubMed).

Ma, Mao, Shen, Zheng, Li, Liu, Ni: "Atractylenolide I-mediated Notch pathway inhibition attenuates gastric cancer stem cell traits." in: Biochemical and biophysical research communications, Vol. 450, Issue 1, pp. 353-9, (2014) (PubMed).

Asnaghi, Lin, Lim, Lim, Tripathy, Wendeborn, Merbs, Handa, Sodhi, Bar, Eberhart: "Hypoxia promotes uveal melanoma invasion through enhanced Notch and MAPK activation." in: PLoS ONE, Vol. 9, Issue 8, pp. e105372, (2014) (PubMed).

Guiu, Shimizu, DAltri, Fraser, Hatakeyama, Bresnick, Kageyama, Dzierzak, Yamamoto, Espinosa, Bigas: "Hes repressors are essential regulators of hematopoietic stem cell development downstream of Notch signaling." in: The Journal of experimental medicine, Vol. 210, Issue 1, pp. 71-84, (2013) (PubMed).

Chu, Liu, Wang: "Overexpression of hCLP46 enhances Notch activation and regulates cell proliferation in a cell type-dependent manner." in: Cell proliferation, Vol. 46, Issue 3, pp. 254-62, (2013) (PubMed).

Asnaghi, Ebrahimi, Schreck, Bar, Coonfield, Bell, Handa, Merbs, Harbour, Eberhart: "Notch signaling promotes growth and invasion in uveal melanoma." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 3, pp. 654-65, (2012) (PubMed).

Ma, Du, Chu, Wang, Liu, Song, Wang: "hCLP46 regulates U937 cell proliferation via Notch signaling pathway." in: Biochemical and biophysical research communications, Vol. 408, Issue 1, pp. 84-8, (2011) (PubMed).

Bennani-Baiti, Aryee, Ban, Machado, Kauer, Mühlbacher, Amann, Llombart-Bosch, Kovar: "Notch signalling is off and is uncoupled from HES1 expression in Ewing's sarcoma." in: The Journal of pathology, Vol. 225, Issue 3, pp. 353-63, (2011) (PubMed).

Schreck, Taylor, Marchionni, Gopalakrishnan, Bar, Gaiano, Eberhart: "The Notch target Hes1 directly modulates Gli1 expression and Hedgehog signaling: a potential mechanism of therapeutic resistance." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 16, Issue 24, pp. 6060-70, (2010) (PubMed).

Tilley, Harvey, Heguy, Hackett, Wang, OConnor, Crystal: "Down-regulation of the notch pathway in human airway epithelium in association with smoking and chronic obstructive pulmonary disease." in: American journal of respiratory and critical care medicine, Vol. 179, Issue 6, pp. 457-66, (2009) (PubMed).
抗原

HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

别名

HES1

背景

Background Information: HES1 belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box.
Gene Name: Hairy and enhancer of split 1, (Drosophila)
Alternative Symbols: HHL, HRY, HES-1, bHLHb39
Protein Name: Transcription factor HES-1

分子量

30 kDa

基因ID

3280

NCBI登录号

NP_005515

UniProt

Q14469

途径

DNA Damage Repair