Expected species reactivity: Bovine, Human, Rat, Xenopus
纯化方法
Antigen affinity purified
免疫原
This mouse Hes1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 102-137 amino acids from the Central region of mouse Hes1.
Titration of the Hes1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
限制
仅限研究用
状态
Liquid
缓冲液
In 1X PBS, pH 7.4, with 0.09 % sodium azide
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
储存方法
Aliquot the Hes1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
抗原
HES1
(Hes Family bHLH Transcription Factor 1 (HES1))
别名
Hes1
背景
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross- link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity).