FGFR1 抗体 (AA 19-48)
Our Local Distributor
北京 101111
Quick Overview for FGFR1 抗体 (AA 19-48) (ABIN3030945)
抗原
See all FGFR1 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- AA 19-48
-
纯化方法
- Purified
-
免疫原
- A portion of amino acids 19-48 from the human protein was used as the immunogen for this FGFR1 antibody.
-
亚型
- Ig Fraction
-
-
-
-
应用备注
- Titration of the FGFR1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Flow Cytometry: 1:10-1:50,Western blot: 1:1000,IHC (Paraffin): 1:50-1:100,Immunofluorescence: 1:50-1:100
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Aliquot the FGFR1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
-
-
- FGFR1 (Fibroblast Growth Factor Receptor 1 (FGFR1))
-
别名
- FGFR1
-
背景
- FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene can lead to Pfeiffer syndrome and Jackson-Weiss syndrome. The genomic organization of the gene is very similar to family members 2-4, encompassing 19 exons that are subject to complex alternative splicing, which allows for structural, tissue expression and ligand affinity variations among the isoforms.
-
UniProt
- P11362
-
途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Sensory Perception of Sound, Stem Cell Maintenance, S100 Proteins
抗原
-