E2F1 抗体 (AA 342-371)
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北京 101111
Quick Overview for E2F1 抗体 (AA 342-371) (ABIN3030786)
抗原
See all E2F1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 342-371
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纯化方法
- Antigen affinity purified
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免疫原
- A portion of amino acids 342-371 from the human protein was used as the immunogen for this E2F1 antibody.
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亚型
- Ig Fraction
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应用备注
- Titration of the E2F1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.\. Western blot: 1:1000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- In 1X PBS, pH 7.4, with 0.09 % sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Aliquot the E2F1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
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- E2F1 (E2F Transcription Factor 1 (E2F1))
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别名
- E2F1
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背景
- E2F1 is a transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters. [UniProt]
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UniProt
- Q01094
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途径
- p53 Pathway, Cell Division Cycle, Mitotic G1-G1/S Phases, DNA Replication, M Phase, Autophagy
抗原
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